항Proliferating Cell Nuclear Antigen 항체 양성의 류마티스관절염 환자 1예

Title
항Proliferating Cell Nuclear Antigen 항체 양성의 류마티스관절염 환자 1예
Other Titles
Anti-Proliferating Cell Nuclear Antigen Antibodies Detected in Rheumatoid Arthritis: A Case Report
Authors
김신규
Keywords
Autoantibody; Proliferating cell nuclear antigen; Rheumatoid arthritis
Issue Date
2015-04
Publisher
대한진단검사의학회
Citation
Laboratory Medicine Online, v. 5, NO 2, Page. 106-109
Abstract
Rheumatoid arthritis (RA) is an autoimmune disease that results in a chronic inflammatory disorder, which principally attacks the small joints. Several autoantibodies, such as rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibody, are known to be associated with RA. Anti-proliferating cell nuclear antigen (PCNA) antibodies are mainly observed in patients with systemic lupus erythematosus (SLE). Indeed, a high titer of these antibodies is considered highly suggestive of SLE; however, anti-PCNA antibodies also appear in other autoimmune diseases. Two previous reports described RA patients with low titers of anti-PCNA antibodies, respectively. In this report, we describe a case of an RA patient exhibiting a high titer (>1:2,560) of anti-PCNA antibodies. The 56-yr-old female patient, with no underlying disease or medication history, presented with multiple joint pain and morning stiffness that had begun 6 months prior. The erythrocyte sedimentation rate (ESR) and RF were elevated (102 mm/hr and 77 IU/mL, respectively), and C-reactive protein (CRP) was 0.8 mg/dL. While the test for anti-CCP antibodies was negative, an anti-PCNA pattern (>1:2,560) and a homogeneous pattern (1:320) were detected by autoimmune target (AIT) test. The presence of anti-PCNA antibodies was subsequently confirmed using the double immunodiffusion method. The anti-dsDNA test was also positive (1:160). X-ray imaging showed soft tissue swelling of multiple joints of both hands and wrists. According to the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria, the patient was classified as having RA. This is the first case to describe high titers anti-PCNA antibodies associated with RA.
URI
http://synapse.koreamed.org/DOIx.php?id=10.3343/lmo.2015.5.2.106http://hdl.handle.net/20.500.11754/24006
ISSN
2093-6338
DOI
http://dx.doi.org/10.3343/lmo.2015.5.2.106
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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