Low Baseline Interleukin-17A Levels Are Associated with Better Treatment Response at 12 Weeks to Tocilizumab Therapy in Rheumatoid Arthritis Patients

Title
Low Baseline Interleukin-17A Levels Are Associated with Better Treatment Response at 12 Weeks to Tocilizumab Therapy in Rheumatoid Arthritis Patients
Authors
유대현
Keywords
I INTERFERON SIGNATURE; DISEASE-ACTIVITY; DOUBLE-BLIND; RECEPTOR INHIBITION; INCOMPLETE RESPONSE; AUTOIMMUNE-DISEASES; TH1 CELLS; T-CELLS; ANTAGONIST; REMISSION
Issue Date
2015-04
Publisher
HINDAWI PUBLISHING CORPORATION
Citation
JOURNAL OF IMMUNOLOGY RESEARCH, v. 2015, NO Article ID 487230, Page. 1-7
Abstract
T helper 17-related cytokines have been implicated in rheumatoid arthritis (RA) pathogenesis. The study aimed to identify cytokines associated with the treatment response of RA patients to tocilizumab (TCZ), a humanized monoclonal antibody against the interleukin- (IL-) 6 receptor. As an independent substudy of the 24-week, randomized, double-blinded CWP-TCZ301 trial of TCZ in RA patients with an inadequate response to disease-modifying antirheumatic drugs, serum levels of cytokines including tumor necrosis factor-alpha, IL-17A, IL-21, IL-23, IL-6, and soluble IL-6 receptor were measured. Baseline IL-17A levels were significantly lower in RA patients who achieved disease activity score 28 (DAS28) remission at 12 weeks of TCZ treatment, compared to patients not in remission. Patients were stratified into IL-17A low group and IL-17A high group. Significantly more patients in the IL-17A low group achieved remission as compared to the IL-17A high group (47.6 versus 17.4%, P = 0.032). DAS28 improvement was significantly better in the IL-17A low group than in the IL-17A high group at 12 weeks (P = 0.045) and 24 weeks (P = 0.046) after adjustment. Other baseline cytokines were not associated with treatment response to TCZ. The data demonstrate that low baseline IL-17A levels are associated with better clinical response to TCZ treatment in RA patients.
URI
https://www.hindawi.com/journals/jir/2015/487230/http://hdl.handle.net/20.500.11754/23996
ISSN
2314-8861; 2314-7156
DOI
http://dx.doi.org/10.1155/2015/487230
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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