The histone acetyltransferase Myst2 regulates Nanog expression, and is involved in maintaining pluripotency and self-renewal of embryonic stem cells

Title
The histone acetyltransferase Myst2 regulates Nanog expression, and is involved in maintaining pluripotency and self-renewal of embryonic stem cells
Authors
채영규
Keywords
Histone acetyltransferase; Embryonic stem cell; Chromatin association; Histone modification
Issue Date
2015-04
Publisher
ELSEVIER SCIENCE BV
Citation
FEBS LETTERS, v. 589, Page. 941-950
Abstract
The histone acetyltransferase Myst2 plays an important role in embryogenesis, but its function in undifferentiated ES cells remains poorly understood. Here, we show that Myst2 plays a role in pluripotency and self-renewal of ES cells. Myst2 deficiency results in loss of characteristic morphology, decreased alkaline phosphatase staining and reduced histone acetylation, as well as aberrant expression of pluripotency and differentiation markers. Our ChIP data reveal a direct association of Myst2 with the Nanog promoter and Myst2-dependent Oct4 binding on the Nanog promoter. Together our data suggest that Myst2-mediated histone acetylation may be required for recruitment of Oct4 to the Nanog promoter, thereby regulating Nanog transcription in ES cells. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
URI
http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.02.029/abstract;jsessionid=2263F6B9E8DEF829AA1A1661F2CE575D.f03t03http://hdl.handle.net/20.500.11754/23979
ISSN
0014-5793; 1873-3468
DOI
http://dx.doi.org/10.1016/j.febslet.2015.02.029
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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