Prognostic Significance of 1-Year Serum Albumin Levels Within the Normal Range After Kidney Transplantation

Title
Prognostic Significance of 1-Year Serum Albumin Levels Within the Normal Range After Kidney Transplantation
Authors
이창화
Keywords
Albumin; Kidney transplantation; Allograft survival; Patient survival; Cardiovascular mortality
Issue Date
2015-04
Publisher
WILEY-BLACKWELL
Citation
ARTIFICIAL ORGANS, v. 39, NO 11, Page. 965-972
Abstract
Hypoalbuminemia is associated with poor outcomes in kidney transplantation (KT). However, what level is optimal in serum albumin is not clear for the long-term prognosis. To determine whether the long-term outcomes are different even between the normal ranges of serum albumin after KT, we analyzed data from 404 renal allograft recipients whose 1-year post-transplant serum albumin levels were within the normal limits (3.5-5.5g/dL). During a follow-up of 122 +/- 56 months, 97 graft losses, 20 patient deaths, and 50 cardiovascular (CV) events occurred. Based on 1-year serum albumin levels, the patients were divided into high normal (4.6g/dL, n=209) and low normal (˂4.6g/dL, n=195) groups. Kaplan-Meier analyses revealed that the low normal group had poorer allograft survival (P=0.01), patient survival (P˂0.001), and CV event-free survival (P˂0.001) than the high normal group. Cox regression analysis confirmed that 1-year serum albumin was inversely associated with the risk of graft loss (hazard ratio [HR] 0.414, 95% confidence interval [CI] 0.200-0.856), patient death (HR 0.097, 95% CI 0.019-0.484), and CV events (HR 0.228, 95% CI 0.074-0.702). In conclusion, a relatively low 1-year post-transplant serum albumin level within the normal limits (˂4.6g/dL) significantly predicts poor long-term outcomes.
URI
http://onlinelibrary.wiley.com/doi/10.1111/aor.12473/abstracthttp://hdl.handle.net/20.500.11754/23801
ISSN
0160-564X; 1525-1594
DOI
http://dx.doi.org/10.1111/aor.12473
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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