Piceatannol inhibits effector T cell functions by suppressing TcR signaling

Title
Piceatannol inhibits effector T cell functions by suppressing TcR signaling
Authors
최제민
Keywords
Piceatannol; T cells; TcR signaling; T cell proliferation; T cell differentiation
Issue Date
2015-04
Publisher
ELSEVIER SCIENCE BV
Citation
INTERNATIONAL IMMUNOPHARMACOLOGY, v. 25, NO 2, Page. 285-292
Abstract
Piceatannol, a metabolite of resveratrol found in red wine and grapes, displays a wide spectrum of biological activity. Although the anti-oxidant, anti-inflammatory, and anti-tumorigenesis activity of piceatannol has been extensively studied, its role in the adaptive immune response has received less attention. Here we investigated the role of piceatannol, a well-known Syk inhibitor, in T cell activation, proliferation, and differentiation using isolated murine splenic T cells from C57BL/6 mice. Piceatannol treatment inhibited surface expression of CD4 and CD8 T cell activation markers CD25 and CD69, reduced production of cytokines IFN gamma, IL-2, and IL-17, and suppressed proliferation of activated T cells. Moreover, piceatannol treatment significantly inhibited differentiation of CD4(+)CD25(-)CD62L(+) naive CD4 T cells into Th1, Th2, and Th17 cells, presumably due to inhibition of TcR signaling through p-Erk, p-Akt, and p-p38. Piceatannol appears to be a useful nutritional or pharmacological biomolecule that regulates effector T cell functions such as cytokine production, differentiation, and proliferation. (C) 2015 Elsevier B.V. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S1567576915000466http://hdl.handle.net/20.500.11754/23763
ISSN
1567-5769; 1878-1705
DOI
http://dx.doi.org/10.1016/j.intimp.2015.01.030
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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