Drosophila blood as a model system for stress sensing mechanisms
- Title
- Drosophila blood as a model system for stress sensing mechanisms
- Author
- 심지원
- Keywords
- Adenosine; Blood progenitors; Drosophila; Hypoxia; Insulin; Lymph gland; Progenitor; ROS; Starvation; Stem cell; Stress; Olfaction
- Issue Date
- 2015-04
- Publisher
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- Citation
- BMB REPORTS, v. 48, NO 4, Page. 223-228
- Abstract
- The Drosophila lymph gland is the hematopoietic organ in which stem-like progenitors proliferate and give rise to myeloid-type blood cells. Mechanisms involved in Drosophila hematopoiesis are well established and known to be conserved in the vertebrate system. Recent studies in Drosophila lymph gland have provided novel insights into how external and internal stresses integrate into blood progenitor maintenance mechanisms and the control of blood cell fate decision. In this review, I will introduce a developmental overview of the Drosophila hematopoietic system, and recent understandings of how the system uses developmental signals not only for hematopoiesis but also as sensors for stress and environmental changes to elicit necessary blood responses.
- URI
- http://koreascience.or.kr/article/ArticleFullRecord.jsp?cn=E1MBB7_2015_v48n4_223http://hdl.handle.net/20.500.11754/23687
- ISSN
- 1976-6696; 1976-670X
- DOI
- 10.5483/BMBRep.2015.48.4.273
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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