Drosophila blood as a model system for stress sensing mechanisms

Title
Drosophila blood as a model system for stress sensing mechanisms
Authors
심지원
Keywords
Adenosine; Blood progenitors; Drosophila; Hypoxia; Insulin; Lymph gland; Progenitor; ROS; Starvation; Stem cell; Stress; Olfaction
Issue Date
2015-04
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Citation
BMB REPORTS, v. 48, NO 4, Page. 223-228
Abstract
The Drosophila lymph gland is the hematopoietic organ in which stem-like progenitors proliferate and give rise to myeloid-type blood cells. Mechanisms involved in Drosophila hematopoiesis are well established and known to be conserved in the vertebrate system. Recent studies in Drosophila lymph gland have provided novel insights into how external and internal stresses integrate into blood progenitor maintenance mechanisms and the control of blood cell fate decision. In this review, I will introduce a developmental overview of the Drosophila hematopoietic system, and recent understandings of how the system uses developmental signals not only for hematopoiesis but also as sensors for stress and environmental changes to elicit necessary blood responses.
URI
http://koreascience.or.kr/article/ArticleFullRecord.jsp?cn=E1MBB7_2015_v48n4_223http://hdl.handle.net/20.500.11754/23687
ISSN
1976-6696; 1976-670X
DOI
http://dx.doi.org/10.5483/BMBRep.2015.48.4.273
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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