Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김영필 | - |
dc.date.accessioned | 2016-09-23T02:20:22Z | - |
dc.date.available | 2016-09-23T02:20:22Z | - |
dc.date.issued | 2015-03 | - |
dc.identifier.citation | MASS SPECTROMETRY REVIEWS, v. 34, NO 2, Page. 237-247 | en_US |
dc.identifier.issn | 0277-7037 | - |
dc.identifier.issn | 1098-2787 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1002/mas.21437/full | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/23303 | - |
dc.description.abstract | Bio-conjugated nanoparticles have emerged as novel molecular probes in nano-biotechnology and nanomedicine and chemical analyses of their surfaces have become challenges. The time-of-flight (TOF) secondary ion mass spectrometry (SIMS) has been one of the most powerful surface characterization techniques for both nanoparticles and biomolecules. When combined with various nanoparticle-based signal enhancing strategies, TOF-SIMS can probe the functionalization of nanoparticles as well as their locations and interactions in biological systems. Especially, nanoparticle-based SIMS is an attractive approach for label-free drug screening because signal-enhancing nanoparticles can be designed to directly measure the enzyme activity. The chemical-specific imaging analysis using SIMS is also well suited to screen nanoparticles and nanoparticle-biomolecule conjugates in complex environments. This review presents some recent applications of nanoparticle-based TOF-SIMS to the chemical analysis of complex biological systems. (c) 2014 Wiley Periodicals, Inc. Mass Spec Rev 34: 237-247, 2015. | en_US |
dc.description.sponsorship | This work was supported by the Bio-Signal Analysis Technology Innovation Program (NRF-2006-2005074), the Converging Research Center for Mass Spectrometric Diagnosis(2013K000429), the Pioneer Research Program (NRF-2012-0009541), Nano Material Technology Development Program (no. 2012M3A7B4035286), Global Frontier Project (H-GU ARD_2013M3A6B2078962) of MSIP/NRF, and the Basic Science Research Programs (no. 20120008222 and no.2012R1A6A1029029) through MOE/NRF. | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY-BLACKWELL | en_US |
dc.subject | TOF-SIMS | en_US |
dc.subject | nanoparticle | en_US |
dc.subject | biomolecule | en_US |
dc.subject | mass imaging | en_US |
dc.subject | surface characterization | en_US |
dc.subject | signal enhancement | en_US |
dc.title | PROBING NANOPARTICLES AND NANOPARTICLE-CONJUGATED BIOMOLECULES USING TIME-OF-FLIGHT SECONDARY ION MASS SPECTROMETRY | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 34 | - |
dc.identifier.doi | 10.1002/mas.21437 | - |
dc.relation.page | 237-247 | - |
dc.relation.journal | MASS SPECTROMETRY REVIEWS | - |
dc.contributor.googleauthor | Kim, Young-Pil | - |
dc.contributor.googleauthor | Shon, Hyun Kyong | - |
dc.contributor.googleauthor | Shin, Seung Koo | - |
dc.contributor.googleauthor | Lee, Tae Geol | - |
dc.relation.code | 2015003456 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | ypilkim | - |
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