PROBING NANOPARTICLES AND NANOPARTICLE-CONJUGATED BIOMOLECULES USING TIME-OF-FLIGHT SECONDARY ION MASS SPECTROMETRY

Title
PROBING NANOPARTICLES AND NANOPARTICLE-CONJUGATED BIOMOLECULES USING TIME-OF-FLIGHT SECONDARY ION MASS SPECTROMETRY
Author
김영필
Keywords
TOF-SIMS; nanoparticle; biomolecule; mass imaging; surface characterization; signal enhancement
Issue Date
2015-03
Publisher
WILEY-BLACKWELL
Citation
MASS SPECTROMETRY REVIEWS, v. 34, NO 2, Page. 237-247
Abstract
Bio-conjugated nanoparticles have emerged as novel molecular probes in nano-biotechnology and nanomedicine and chemical analyses of their surfaces have become challenges. The time-of-flight (TOF) secondary ion mass spectrometry (SIMS) has been one of the most powerful surface characterization techniques for both nanoparticles and biomolecules. When combined with various nanoparticle-based signal enhancing strategies, TOF-SIMS can probe the functionalization of nanoparticles as well as their locations and interactions in biological systems. Especially, nanoparticle-based SIMS is an attractive approach for label-free drug screening because signal-enhancing nanoparticles can be designed to directly measure the enzyme activity. The chemical-specific imaging analysis using SIMS is also well suited to screen nanoparticles and nanoparticle-biomolecule conjugates in complex environments. This review presents some recent applications of nanoparticle-based TOF-SIMS to the chemical analysis of complex biological systems. (c) 2014 Wiley Periodicals, Inc. Mass Spec Rev 34: 237-247, 2015.
URI
http://onlinelibrary.wiley.com/doi/10.1002/mas.21437/fullhttp://hdl.handle.net/20.500.11754/23303
ISSN
0277-7037; 1098-2787
DOI
10.1002/mas.21437
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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