Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 주재범 | - |
dc.date.accessioned | 2016-09-20T00:43:34Z | - |
dc.date.available | 2016-09-20T00:43:34Z | - |
dc.date.issued | 2015-03 | - |
dc.identifier.citation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v. 36, Page. 822-826 | en_US |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.issn | 1229-5949 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/http://onlinelibrary.wiley.com/doi/10.1002/bkcs.10154/full | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/23219 | - |
dc.description.abstract | Anthrax is a highly acute disease caused by the bacterium Bacillus anthracis. In this article, we report a highly sensitive detection technique for pathogenic B. anthracis, based on the use of a surface-enhanced Raman scattering (SERS)-active magnetic sensor. Gold nanoparticles (GNPs) and magnetic beads were used as SERS nanotags and supporting substrates, respectively. Here, an SERS-based competitive immunoassay platform is described for the quantitative evaluation of the anthrax marker. Poly-gamma-D-glutamic acid (PGA) capsules were used as a target biomarker for the highly sensitive detection of B. anthracis becausePGAis known to be closely associated with the pathogenesis of B. anthracis infection. The SERS-based competitive assay reveals an extraordinarily high sensitivity for PGA with a limit of detection of similar to 1.0 ng/mL. This work provides a conceptually new immunoassay prototype for fast and sensitive detection of PGA markers. | en_US |
dc.description.sponsorship | This work was supported by the Research of Korea Centers for Disease Control and Prevention (2014-E45002-00). This research was also supported by the Nano Material Technology Development Program through the National Research Foundation of Korea funded by the Ministry of Education, Science, and Technology (2012035286). | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN CHEMICAL SOC | en_US |
dc.subject | Surface-enhanced Raman scattering | en_US |
dc.subject | Bacillus anthracis | en_US |
dc.subject | Poly-gamma-D-glutamic acid | en_US |
dc.subject | Competitive immunoassay | en_US |
dc.subject | Magnetic bead | en_US |
dc.title | Surface-enhanced Raman Scattering-based Competitive Immunoassay of Poly-gamma-D-Glutamic Acid for Highly Sensitive Detection of Anthrax Biomarker | en_US |
dc.type | Article | en_US |
dc.relation.volume | 36 | - |
dc.identifier.doi | 10.1002/bkcs.10154 | - |
dc.relation.page | 822-826 | - |
dc.relation.journal | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.contributor.googleauthor | Juhui, Ko. | - |
dc.contributor.googleauthor | Kiweon, Cha. | - |
dc.contributor.googleauthor | Jun Ho, Jeon. | - |
dc.contributor.googleauthor | Gi-Eun, Rhie. | - |
dc.contributor.googleauthor | Jonghoon, Choi. | - |
dc.contributor.googleauthor | Jaebum, Choo. | - |
dc.relation.code | 2015003699 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | jbchoo | - |
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