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dc.contributor.author배상철-
dc.date.accessioned2016-09-20T00:14:19Z-
dc.date.available2016-09-20T00:14:19Z-
dc.date.issued2015-03-
dc.identifier.citationZEITSCHRIFT FUR RHEUMATOLOGIE, v. 74, NO 2, Page. 146-152en_US
dc.identifier.issn0340-1855-
dc.identifier.issn1435-1250-
dc.identifier.urihttp://link.springer.com/article/10.1007%2Fs00393-014-1409-9-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/23216-
dc.description.abstractObjective The aim of this study was to determine whether the major histocompatibility complex class I chain-related gene A transmembrane (MICA-TM) polymorphism is associated with susceptibility to systemic lupus erythematous (SLE), rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Methods A meta-analysis was conducted to establish the association between MICA-TM polymorphisms and SLE, RA and AS in the overall study population, as well as in each ethnic group. Results A total of 13 comparison studies, including five SLE (1601 patients; 1846 controls), four RA (701 patients; 887 controls) and four AS (346 patients; 356 controls) studies were considered in the meta-analysis. An association between the MICA-TM A5.1 allele and SLE was demonstrated in Europeans but not in Asians: odds ratio (OR) = 1.699, 95 % confidence interval (CI) = 1.123–2.569, p = 0.012 and OR = 0.949, 95 % CI = 0.502–1.793, p = 0.871, respectively. However, no association was found in Europeans after Bonferroni correction (pcorrected = 0.060). An association was found between the MICA-TM A9 allele and RA in Asians (OR = 0.527, 95 % CI = 0.408–0.681, p = 8.9 × 10−7) but not in Europeans; the association in Asians remained significant after Bonferroni correction (pcorrected = 4.5 × 10−6). An association between the MICA-TM A4 phenotype and AS was observed in European and Asian populations (OR = 12.87, 95 % CI = 6.747–24.58, p < 1.0 × 10−9 and OR = 9.461, 95 % CI = 5.754–15.55, p < 1.0 × 10−9, respectively). Meta-analysis stratified by human leukocyte antigen (HLA)-B27 status revealed an association between the MICA-TM A4 phenotype and HLA-B27 positivity AS in Asians, but not in Europeans (OR = 0.318, 95 % CI = 0.102–0.995, p = 0.049 and OR = 2.080, 95 % CI = 0.422–10.25, p = 0.368, respectively). However, the association in Asians was not significant after Bonferroni correction (pcorrected = 0.245). Conclusion This meta-analysis demonstrated that there was no association between MICA-TM polymorphisms and SLE susceptibility, but that the MICA-TM A9 allele was associated with an RA risk in Asians. Moreover, the association between the MICA-TM A4 phenotype and AS was HLA-B27-dependent.en_US
dc.description.sponsorshipThis study was supported in part by a grant of the Korea Healthcare technology R&D project, Ministry for Health & Welfare, Republic of Korea (HI12C1834).en_US
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.subjectHLA-B27 antigenen_US
dc.subjectMajor histocompatibility complexen_US
dc.subjectAutoimmune diseaseen_US
dc.subjectEthnic groupsen_US
dc.subjectGenetic association studiesen_US
dc.titleMeta-analysis of the association between functional MICA-TM polymorphisms and systemic lupus erythematosus, rheumatoid arthritis and ankylosing spondylitisen_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume74-
dc.identifier.doi10.1007/s00393-014-1409-9-
dc.relation.page146-152-
dc.relation.journalZEITSCHRIFT FUR RHEUMATOLOGIE-
dc.contributor.googleauthorLee, Y.H.-
dc.contributor.googleauthorBae, S.C.-
dc.contributor.googleauthorKim, J.H.-
dc.contributor.googleauthorSong, G.G.-
dc.relation.code2015001130-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidscbae-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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