Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2016-09-20T00:14:19Z | - |
dc.date.available | 2016-09-20T00:14:19Z | - |
dc.date.issued | 2015-03 | - |
dc.identifier.citation | ZEITSCHRIFT FUR RHEUMATOLOGIE, v. 74, NO 2, Page. 146-152 | en_US |
dc.identifier.issn | 0340-1855 | - |
dc.identifier.issn | 1435-1250 | - |
dc.identifier.uri | http://link.springer.com/article/10.1007%2Fs00393-014-1409-9 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/23216 | - |
dc.description.abstract | Objective The aim of this study was to determine whether the major histocompatibility complex class I chain-related gene A transmembrane (MICA-TM) polymorphism is associated with susceptibility to systemic lupus erythematous (SLE), rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Methods A meta-analysis was conducted to establish the association between MICA-TM polymorphisms and SLE, RA and AS in the overall study population, as well as in each ethnic group. Results A total of 13 comparison studies, including five SLE (1601 patients; 1846 controls), four RA (701 patients; 887 controls) and four AS (346 patients; 356 controls) studies were considered in the meta-analysis. An association between the MICA-TM A5.1 allele and SLE was demonstrated in Europeans but not in Asians: odds ratio (OR) = 1.699, 95 % confidence interval (CI) = 1.123–2.569, p = 0.012 and OR = 0.949, 95 % CI = 0.502–1.793, p = 0.871, respectively. However, no association was found in Europeans after Bonferroni correction (pcorrected = 0.060). An association was found between the MICA-TM A9 allele and RA in Asians (OR = 0.527, 95 % CI = 0.408–0.681, p = 8.9 × 10−7) but not in Europeans; the association in Asians remained significant after Bonferroni correction (pcorrected = 4.5 × 10−6). An association between the MICA-TM A4 phenotype and AS was observed in European and Asian populations (OR = 12.87, 95 % CI = 6.747–24.58, p < 1.0 × 10−9 and OR = 9.461, 95 % CI = 5.754–15.55, p < 1.0 × 10−9, respectively). Meta-analysis stratified by human leukocyte antigen (HLA)-B27 status revealed an association between the MICA-TM A4 phenotype and HLA-B27 positivity AS in Asians, but not in Europeans (OR = 0.318, 95 % CI = 0.102–0.995, p = 0.049 and OR = 2.080, 95 % CI = 0.422–10.25, p = 0.368, respectively). However, the association in Asians was not significant after Bonferroni correction (pcorrected = 0.245). Conclusion This meta-analysis demonstrated that there was no association between MICA-TM polymorphisms and SLE susceptibility, but that the MICA-TM A9 allele was associated with an RA risk in Asians. Moreover, the association between the MICA-TM A4 phenotype and AS was HLA-B27-dependent. | en_US |
dc.description.sponsorship | This study was supported in part by a grant of the Korea Healthcare technology R&D project, Ministry for Health & Welfare, Republic of Korea (HI12C1834). | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPRINGER HEIDELBERG | en_US |
dc.subject | HLA-B27 antigen | en_US |
dc.subject | Major histocompatibility complex | en_US |
dc.subject | Autoimmune disease | en_US |
dc.subject | Ethnic groups | en_US |
dc.subject | Genetic association studies | en_US |
dc.title | Meta-analysis of the association between functional MICA-TM polymorphisms and systemic lupus erythematosus, rheumatoid arthritis and ankylosing spondylitis | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 74 | - |
dc.identifier.doi | 10.1007/s00393-014-1409-9 | - |
dc.relation.page | 146-152 | - |
dc.relation.journal | ZEITSCHRIFT FUR RHEUMATOLOGIE | - |
dc.contributor.googleauthor | Lee, Y.H. | - |
dc.contributor.googleauthor | Bae, S.C. | - |
dc.contributor.googleauthor | Kim, J.H. | - |
dc.contributor.googleauthor | Song, G.G. | - |
dc.relation.code | 2015001130 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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