Ethanol toxicity affects olfactory receptor genes in forebrain of fetal mice

Title
Ethanol toxicity affects olfactory receptor genes in forebrain of fetal mice
Author
채영규
Keywords
Prenatal alcohol exposure; Binge alcohol; Microarray; Olfactory transduction; Odor detection
Issue Date
2015-03
Publisher
KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
Citation
MOLECULAR & CELLULAR TOXICOLOGY, v. 11, Page. 55-60
Abstract
Toxicity of ethanol can lead to behavioral and cognitive impairments of fetus. The aim of this current study was to investigate the alteration of genes at developing fetal brain by maternal binge alcohol consumption. Genome-wide transcriptional analysis revealed a set of differentially expressed genes (20 upregulated and 21 down-regulated; 1.5-fold cut-off) on embryonic day 15 (ED 15) in the developing fetal brain. The gene ontology analysis revealed the associations of these genes with sensory perception, whereas Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that they were correlated with olfactory transduction. Six olfactory receptor genes (Olfr960, Olfr1342, Olfr43, Olfr836, Olfr1262 and Olfr1419) encoding proteins involved in the olfactory transduction pathway showed reduced expression levels. The down-regulation of these olfactory receptor genes may cause odor identification defects as well as abnormalities in the olfactory system. Our findings aid in the elucidation of the molecular mechanism underlying the defective olfactory processing that occurs following prenatal alcohol exposure.
URI
http://link.springer.com/article/10.1007/s13273-015-0007-5http://hdl.handle.net/20.500.11754/22984
ISSN
1738-642X; 2092-8467
DOI
10.1007/s13273-015-0007-5
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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