Alteration of laboratory findings after radiofrequency ablationof hepatocelluar carcinoma: relationship to severity of the underlying liver disease and the ablation volume

Title
Alteration of laboratory findings after radiofrequency ablationof hepatocelluar carcinoma: relationship to severity of the underlying liver disease and the ablation volume
Authors
김용수
Keywords
Alanine aminotransferase; Child-Pugh class; Hepatocellular carcinoma; Leukocytosis; Radiofrequency ablation
Issue Date
2015-03
Publisher
대한간학회
Citation
Clinical and Molecular Hepatology, v. 21, NO 1, Page. 71-79
Abstract
Background/Aims To investigate sequential changes in laboratory markers after radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) and the relationship of these changes to the severity of the underlying liver disease. Methods This retrospective analysis included 65 patients (44 males, 21 females) who underwent RFA of HCC. Hematologic and biochemical markers were assessed at the pre-RFA period and 1 day, 2-3 days, and 1-2 weeks after RFA. We classified the subjects into two groups: Child-Pugh A (n=41) and Child-Pugh B (n=24). The ablative margin volume (AMV) of each patient was measured. We analyzed the changes in laboratory profiles from the baseline, and investigated whether these laboratory changes were correlated with the AMV and the Child-Pugh classification. Results Most of the laboratory values peaked at 2-3 days after RFA. AMV was significantly correlated with changes in WBC count, hemoglobin level, and serum total bilirubin level (Pearson's correlation coefficient, 0.324-0.453; P<0.05). The alanine aminotransferase (ALT) level varied significantly over time (P=0.023). Conclusions Most of the measured laboratory markers changed from baseline, peaking at 2-3 days. The ALT level was the only parameter for which there was a significant difference after RFA between Child-Pugh A and B patients: it increased significantly more in the Child-Pugh A patients.
URI
http://e-cmh.org/journal/view.php?doi=10.3350/cmh.2015.21.1.71http://hdl.handle.net/20.500.11754/22818
ISSN
2287-2728; 2287-285X
DOI
http://dx.doi.org/10.3350/cmh.2015.21.1.71
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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