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dc.contributor.author박준성-
dc.date.accessioned2016-08-26T00:59:46Z-
dc.date.available2016-08-26T00:59:46Z-
dc.date.issued2015-03-
dc.identifier.citationARTIFICIAL ORGANS, v. 39, NO 3, Page. 254-259en_US
dc.identifier.issn0160-564X-
dc.identifier.issn1525-1594-
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1111/aor.12367/full-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/22782-
dc.description.abstractReserve capacity of donated kidney may be an important determinant of allograft survival in kidney transplantation (KT). Here, we investigate change in estimated glomerular filtration rate of donor kidney (Delta eGFR(Donor)) over 30 days after KT as a predictor of the allograft function. A total of 222 recipients were divided into two groups according to Delta eGFR(Donor) as follows: Group I (n = 110), Delta eGFR(Donor) >= -25%; Group II (n = 112), Delta eGFR(Donor) < -25%. Three years after KT, Group I had a higher eGFR(Recipient) than Group II (55 +/- 21 vs. 47 +/- 22 mL/min/1.73 m(2), P < 0.05). However, no differences in eGFR(Recipient) were detected between the two groups after 10 years. Linear regression analysis showed that Delta eGFR(Donor) was significantly associated with the eGFR(Recipient) at 3 years post-transplantation, but not at 10 years post-transplantation. In Kaplan-Meier analysis, Group I had a greater dialysis-free survival rate than Group II at the 10-year follow-up (84% vs. 76%, P < 0.05). However, no difference in overall survival rate between groups was detected. In the multivariate-adjusted Cox proportional-hazard model, Delta eGFR(Donor) was independently associated with future allograft loss (hazard ratio 0.973; 95% confidence interval 0.949-0.999). These results suggest that larger recovery of donor kidney function after KT donation is associated with better short/intermediate-term allograft outcomes. Follow-up assessment of donor kidney function may be useful to monitor KT recipients at risk for allograft loss.en_US
dc.description.sponsorshipHanyang Universityen_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.subjectKidney transplantationen_US
dc.subjectGlomerular filtration rateen_US
dc.subjectOutcomeen_US
dc.titleAssociation Between a Change in Donor Kidney Function and Long-Term Allograft Outcomes in Kidney Transplant Recipientsen_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume39-
dc.identifier.doi10.1111/aor.12367-
dc.relation.page254-259-
dc.relation.journalARTIFICIAL ORGANS-
dc.contributor.googleauthorOh, Il-Hwan-
dc.contributor.googleauthorLee, Chang-Hwa-
dc.contributor.googleauthorKim, Gheun-Ho-
dc.contributor.googleauthorKang, Chong-Myung-
dc.contributor.googleauthorPark, Joon-Sung-
dc.relation.code2015000287-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidsjpjoon-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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