Transcranial direct current stimulation on primary sensorimotor area has no effect in patients with drug- naive restless legs syndrome: a proof-of-concept clinical trial

Title
Transcranial direct current stimulation on primary sensorimotor area has no effect in patients with drug- naive restless legs syndrome: a proof-of-concept clinical trial
Authors
임창환
Keywords
Restless legs syndrome; Transcranial direct current stimulation; Cortical excitability; Non-pharmacological treatment; Event-related synchronization
Issue Date
2015-02
Publisher
ELSEVIER SCIENCE BV
Citation
SLEEP MEDICINE, v. 16, NO 2, Page. 280-287
Abstract
Objective: To evaluate the efficacy of transcranial direct current stimulation (tDCS) in people with drugnaive restless legs syndrome (RLS). Methods: A two-week, double-blind, randomized, sham-controlled trialwas performed. Thirty-three females with RLS were recruited. Participants received five sessions of tDCS using cathodal, anodal or sham stimulation. They were assessed at baseline (T0), three days (T1) and 13 days (T2) after the end of tDCS. Primary outcomes included the International RLS Group Rating Scale (IRLS) and the Clinical Global ImpressionsImprovement (CGI-I). Secondary outcomes included the Patient Global Impression scale, the Pittsburgh Sleep Quality Index, the Medical Outcome Study sleep subscales, and the Beck Depression Inventory. Objective neurophysiological changes were assessed using event-related desynchronization/synchronization (ERD/ERS) of electroencephalography. Results: The changes in the IRLS scores, as well as the responder rate in the CGI-I scale, did not differ significantly among the groups. There was also no significant difference in any of the secondary outcome measures and ERD/ERS among the groups. Conclusions: Transcranial direct current stimulation with electrodes on the sensorimotor areas showed no significant effect in people with drug-naive RLS. (C) 2014 Elsevier B.V. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S1389945714004729http://hdl.handle.net/20.500.11754/22460
ISSN
1389-9457; 1878-5506
DOI
http://dx.doi.org/10.1016/j.sleep.2014.07.032
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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