Inverse association between visceral obesity and lymph node metastasis in gastric cancer.

Title
Inverse association between visceral obesity and lymph node metastasis in gastric cancer.
Author
이오영
Keywords
Obesity; Visceral fat area; Lymph node; Metastasis; Gastric cancer
Issue Date
2015-02
Publisher
Springer
Citation
Journal of Gastrointestinal Surgery, v. 19, NO 2, Page. 242-250
Abstract
The relationship between fat distribution and lymph node metastasis has not been well studied. The goal of this study was to determine the impact of visceral obesity on lymph node metastasis in gastric cancer. Metastatic lymph node ratio (MLR) was defined as the number of involved nodes by tumor divided by the total number of resected lymph nodes. Visceral (VFA) and subcutaneous fat areas (SFA) were determined by measuring abdominal fat volume distribution via CT scan, and visceral obesity was defined as a VFA to total fat area ratio (V/T) > 0.29. With lymph node metastasis as a dependent variable, the following factors were significant in multivariate analysis among 495 patients: pathologic T stage (P < 0.001), lympho-vascular invasion (P < 0.001), and V/T (hazard ratio (HR) = 0.455, 95 % confidence interval (CI) = 0.263-0.786, P = 0.005). Similarly, when MLR was the dependent variable in multivariate analysis, MLR was significantly associated with lympho-vascular invasion (HR = 2.222, 95 % CI = 1.149-4.296, P = 0.018), and V/T (HR = 0.247, 95 % CI = 0.133-0.458, P < 0.001). Visceral obesity defined by higher visceral to total fat area ratio was significantly associated with decreased MLR.
URI
http://link.springer.com/article/10.1007/s11605-014-2682-2http://hdl.handle.net/20.500.11754/22408
ISSN
1091-255X; 1873-4626
DOI
10.1007/s11605-014-2682-2
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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