The Association of Normal Range Glycated Hemoglobin with Restrictive Lung Pattern in the General Population

Title
The Association of Normal Range Glycated Hemoglobin with Restrictive Lung Pattern in the General Population
Authors
박준성
Keywords
DIABETES-MELLITUS; VASCULAR COMPLICATIONS; SYSTEMIC
Issue Date
2015-02
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE, v. 10, NO 2, Page. 1-10
Abstract
Glycated hemoglobin (HbA1c) is an important diagnostic indicator of diabetes mellitus, and some authors have argued that it is related to impaired lung function in the diabetic population. However, there was rare study for association between lung function and HbA1c in the non-diabetic population. We investigated whether HbA1c below the diagnostic threshold is related to deficits in lung function. We analyzed biochemical and spirometry data from a nation-wide, population-based, case-control study (the KNHANES IV and V). Eligible as cases were all native Koreans aged 40 years or more with no medical illness. A total of 3670 participants were divided into 4 groups according to HbA1c (%) as follows: Group I (n = 842), >= 4.0 and <= 5.3; Group II (n = 833), >5.3 and <= 5.5; Group III (n = 898), >5.5 and <= 5.7; and Group IV (n = 1097), >5.7 and <= 6.4. Group I had the greatest forced vital capacity (FVC, 96.3 +/- 0.5% pred, P < 0.0001), forced expiratory volume per second (FEV1, 93.8 +/- 0.5% pred, P < 0.0001) and FEV1/FVC (0.792 +/- 0.003, P < 0.0001) compared with the other groups. Linear regression showed that HbA1c was closely related to FVC (beta = -6.972154, P < 0.0001) and FEV1 (beta = -5.591589, P < 0.0001), but not to FEV1/FVC. Logistic regression analysis revealed a significant association between HbA1c and a restrictive spirometric pattern (FVC < 80% pred., FEV1/FVC >= 0.70; OR = 3.772, 95% CI = 1.234-11.53), indicating that elevated HbA1c is closely associated with lung impairment in the non-diabetic population. In the healthy population, relatively high HbA1c level is associated with decrements of FVC and FEV1 and may be a reliable predictor of poor lung function, especially the restrictive pattern.
URI
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117725http://hdl.handle.net/20.500.11754/22310
ISSN
1932-6203
DOI
http://dx.doi.org/10.1371/journal.pone.0117725
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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