The influence of mild hypothermia on reversal of rocuronium-induced deep neuromuscular block with sugammadex

Title
The influence of mild hypothermia on reversal of rocuronium-induced deep neuromuscular block with sugammadex
Authors
김교상
Keywords
Hypothermia; Neuromuscular blockade Rocuronium; Sugammadex
Issue Date
2015-02
Publisher
BIOMED CENTRAL LTD
Citation
BMC ANESTHESIOLOGY, v. 15, NO 7, Page. 1-6
Abstract
Background: Mild hypothermia may be frequently induced due to cool environments in the operating room. The study analyzed patient recovery time and response to sugammadex after a prolonged rocuronium-induced deep neuromuscular block (NMB) during mild hypothermia. Methods: Sixty patients were randomly (1: 1) allocated to the mild hypothermia and normothermia groups, defined as having core temperatures between 34.5 -35 degrees C and 36.5-37 degrees C, respectively. Patients received 0.6 mg/kg of rocuronium, followed by 7-10 mu g/kg/min to maintain a deep NMB [post-tetanic count (PTC) 1-2]. After surgery, the deep NMB was reversed with sugammadex 4.0 mg/kg. The primary end-point was the time until the train-of-four (TOF) ratio was 0.9. Results: The appropriate neuromuscular function (TOF ratio >= 0.9) was restored after sugammadex was administered, even after hypothermia. The length of recovery in the hypothermia patients [mean (SD), 171.1 (62.1) seconds (s)] was significantly slower compared with the normothermia patients [124.9 (59.2) s] (p = 0.005). There were no adverse effects from sugammadex. Conclusions: Sugammadex safely and securely reversed deep rocuronium-induced NMB during mild hypothermia. An additional 46 s was required for recovery from a deep NMB in hypothermia patients. Based on the results, we think this prolonged recovery time is clinically acceptable.
URI
http://bmcanesthesiol.biomedcentral.com/articles/10.1186/1471-2253-15-7http://hdl.handle.net/20.500.11754/22139
ISSN
1471-2253
DOI
http://dx.doi.org/10.1186/1471-2253-15-7
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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