Recent advances in systemic lupus erythematosus genetics in an Asian population

Title
Recent advances in systemic lupus erythematosus genetics in an Asian population
Authors
이혜순
Keywords
ethnicity; genetics; genome-wide association study; systemic lupus erythematosus
Issue Date
2015-02
Publisher
WILEY-BLACKWELL
Citation
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, v. 18, NO 2, Page. 192-199
Abstract
Recent advances in systemic lupus erythematosus (SLE) genetics in Asian populations have been achieved by genome-wide association studies (GWASs) and following replication studies, which expanded the genetic information about shared or population-specific risk genes between ethnic groups. Meta-analyses and multi-ethnic replication studies may be possible approaches that could demonstrate stronger or more suggestive evidence for multiple variants for SLE. In addition to the susceptibility of SLE itself, several genotype-phenotype analyses have shown that the specific phenotypes of SLE can also be influenced by genetic factors. Almost all SLE genetic loci are involved in the potential pathways of SLE pathogenesis, such as Toll-like receptor/type I interferon signaling, nuclear factor B signaling, immune complex clearing mechanism, immune cell (B, T cell, neutrophil and monocyte) function and signaling, cell-cycle regulation, DNA methylation and autophagy. Further studies, including the next generation sequencing technology and the systematic strategy using bioinformatics, in addition to international collaboration among SLE genetic researchers, will give us better understanding of the genetic basis of SLE.
URI
http://onlinelibrary.wiley.com/doi/10.1111/1756-185X.12498/abstracthttp://hdl.handle.net/20.500.11754/22120
ISSN
1756-1841; 1756-185X
DOI
http://dx.doi.org/10.1111/1756-185X.12498
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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