Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hyunsook Kim | - |
dc.date.accessioned | 2016-07-15T04:27:36Z | - |
dc.date.available | 2016-07-15T04:27:36Z | - |
dc.date.issued | 2015-01 | - |
dc.identifier.citation | Journal of Traditional and Complementary Medicine, v. 5, NO 1, Page. 56-61 | en_US |
dc.identifier.issn | 2225-4110 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/22041 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S2225411014000042 | - |
dc.description.abstract | Brasenia schreberi (chún cai) is an invasive aquatic weed found in the USA, but the plant has economic value in Asia where it is cultivated for food. The young leaves of B. schreberi are coated with gelatinous water-insoluble mucilage. This mucilage is a polysaccharide composed of galactose, mannose, fucose, and other monosaccharides. Because some carbohydrate gels are hypocholesterolemic, we evaluated their cholesterol-lowering properties in male hamsters fed hypercholesterolemic diets containing 2% gel coat from B. schreberi (GEL), or 1% cholestyramine (CA), or 5% hydroxypropyl methylcellulose (HPMC), and compared them to 5% microcrystalline cellulose (control) for 3 weeks. We found that very-low-density lipoprotein-, low-density lipoprotein-, and total-cholesterol concentrations in plasma were significantly lowered by GEL, CA, and HPMC compared to control. High-density lipoproteincholesterol concentration was lowered by CA and HPMC. Body weights and abdominal adipose tissue weight of GEL and control group animals were greater than those of the CA and HPMC groups. Fecal lipid excretion was greater in the CA and HPMC groups than in the control group. Expression of hepatic CYP51 and CYP7A1 mRNA was upregulated by CA, HPMC, and GEL, indicating increased hepatic cholesterol and bile acid synthesis. Expression of low-density lipoprotein receptor mRNA was upregulated by all treatments. These results suggest that modulation of hepatic expression of cholesterol and bile acid metabolism-regulated genes contributes to the cholesterol-lowering effects of GEL. | - |
dc.description.sponsorship | H.K. was supported by KU Research Professor Program of Konkuk University, Seoul, Korea. | - |
dc.language.iso | en | - |
dc.publisher | Wolters Kluwer Health | en_US |
dc.subject | Brasenia | - |
dc.subject | cholesterol | - |
dc.subject | gene expression | - |
dc.subject | hamster | - |
dc.subject | polysaccharide | - |
dc.title | Polysaccharide gel coating of the leaves of Brasenia schreberi lowers plasma cholesterol in hamsters | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 5 | - |
dc.identifier.doi | 10.1016/j.jtcme.2014.10.003 | - |
dc.relation.page | 56-61 | - |
dc.relation.journal | Journal of Traditional and Complementary Medicine | - |
dc.contributor.googleauthor | Kim, Hyunsook | - |
dc.contributor.googleauthor | Wang, Qian | - |
dc.contributor.googleauthor | Shoemaker, Charles F. | - |
dc.contributor.googleauthor | Zhong, Fang | - |
dc.contributor.googleauthor | Bartley, Glenn E. | - |
dc.contributor.googleauthor | Yokoyama, Wallace H. | - |
dc.relation.code | 2015031221 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF HUMAN ECOLOGY[S] | - |
dc.sector.department | MAJOR IN FOOD & NUTRITION | - |
dc.identifier.pid | hyunsk15 | - |
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