Biological functions of hyaluronan and cytokine-inducible deubiquitinating enzymes

Title
Biological functions of hyaluronan and cytokine-inducible deubiquitinating enzymes
Author
Ramakrishna Suresh
Keywords
Apoptosis; Bioconjugates; CD44; DUB enzyme; Hyaluronan; Tumor
Issue Date
2015-01
Publisher
ELSEVIER SCIENCE BV
Citation
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, v. 1855, Page. 83-91
Abstract
The modification of proteins through post-translation and degradation by the ubiquitin-proteasome system plays a pivotal role in a broad array of biological processes. Reversal of this process by deubiquitination is a central step in the maintenance and regulation of cellular homeostasis. It now appears that the regulation of ubiquitin pathways by deubiquitinating enzymes (DUBS) could be used as targets for anticancer therapy. Recent success in inducing apoptosis in cancerous cells by USP17, a cytokine-inducible DUB encoding two hyaluronan binding motifs (HABMs) showing direct interaction with hyaluronan (HA), could prove a promising step in the development of DUBs containing HABMs as agents in anticancer therapeutics. In this review, we summarize the importance of hyaluronan (HA) in cancer, the role played by DUBs in apoptosis, and a possible relationship between DUBs and HA in cancerous cells, suggesting new strategies for applying DUB enzymes as potential anticancer therapeutics. (C) 2014 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/20.500.11754/21724http://www.sciencedirect.com/science/article/pii/S0304419X14001103
ISSN
0304-419X
DOI
10.1016/j.bbcan.2014.11.006
Appears in Collections:
GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > ETC
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