Three-month Treatment Response and Exacerbation in Chronic Obstructive Pulmonary Disease

Title
Three-month Treatment Response and Exacerbation in Chronic Obstructive Pulmonary Disease
Author
김태형
Keywords
Pulmonary Disease; Chronic Obstructive; Forced Expiratory Volume; Disease Progression
Issue Date
2015-01
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v. 30, NO 1, Page. 54-59
Abstract
The aim of this study was to investigate relationships between acute exacerbation and Forced Expiratory Volume 1 second (FEV1) improvement after treatment with combined long-acting beta-agonist (LABA) and inhaled corticosteroid (ICS) in patients with chronic obstructive pulmonary disease (COPD). A total of 137 COPD patients were classified as responders or nonresponders according to FEV1 improvement after 3 months of LABA/ICS treatment in fourteen referral hospitals in Korea. Exacerbation occurrence in these two subgroups was compared over a period of 1 yr. Eighty of the 137 COPD patients (58.4%) were classified as responders and 57 (41.6%) as nonresponders. Acute exacerbations occurred in 25 patients (31.3%) in the responder group and in 26 patients (45.6%) in the nonresponder group (P = 0.086). FEV1 improvement after LABA/ICS treatment was a significant prognostic factor for fewer acute exacerbations in a multivariate Cox proportional hazard model adjusted for age, sex, FEV1, smoking history, 6 min walk distance, body mass index, exacerbation history in the previous year, and dyspnea scale. Three-month treatment response to LABA/ICS might be a prognostic factor for the occurrence of acute exacerbation in COPD patients.
URI
http://hdl.handle.net/20.500.11754/21684https://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2015.30.1.54
ISSN
1011-8934
DOI
10.3346/jkms.2015.30.1.54
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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