Vitamin D Deficiency Disrupts Neuronal Integrity in Cognitively Impaired Patients

Title
Vitamin D Deficiency Disrupts Neuronal Integrity in Cognitively Impaired Patients
Author
이종민
Keywords
nutritional; vitamin D; imaging; Cognitive decline
Issue Date
2015-01
Publisher
IOS PRESS
Citation
JOURNAL OF ALZHEIMERS DISEASE, v. 45, NO 4, Page. 1089-1096
Abstract
Background: Emerging evidence suggests that low serum 25-hydroxyvitamin D (25OHD) may induce cognitive decline and dementia, however, the pathophysiological mechanisms are poorly understood. Objective: We sought to determine the relationship between vitamin D deficiency and neuronal integrity in cognitively impaired patients. Methods: One hundred nine patients with memory impairment were divided into quartiles according to serum concentrations of 25OHD concentration, from lowest (L-25OHD) to highest (H-25OHD). The diffusion tensor images from the L-25OHD group and the H-25OHD group were assessed. A mask of regional white matter hyperintensities was obtained in the T1-weighted image space. Data were analyzed using tract-based spatial statistics with a nonlinear registration algorithm. Results: Patients in the L-25OHD group had lower fractional anisotropy values compared with patients in the H-25OHD group in the frontal parts of the inferior and superior longitudinal fasciculi, cingulum bundle, corpus callosum (genu), anterior limb of the internal capsule, and anterior corona radiata (familywise error corrected, p ˂ 0.05). Conclusions: Vitamin D deficiency is associated with disruption of neuronal integrity, primarily in frontal regions. Vitamin D deficiency may lead to the loss of neuroprotective properties in cerebral ischemia and vascular lesions, contributing to memory impairment.
URI
http://hdl.handle.net/20.500.11754/21644http://content.iospress.com/articles/journal-of-alzheimers-disease/jad143063
ISSN
1387-2877
DOI
10.3233/JAD-143063
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE