Single Nucleotide Polymorphisms of Ataxia Telangiectasia Mutated and the Risk of Papillary Thyroid Carcinoma

Title
Single Nucleotide Polymorphisms of Ataxia Telangiectasia Mutated and the Risk of Papillary Thyroid Carcinoma
Author
지용배
Keywords
ataxia tela ngiectasia mutated; single nucleotide polymorphism; papillary t hyroid carcinoma; genetic polymorphism
Issue Date
2015-01
Publisher
WILEY-BLACKWELL
Citation
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, v. 56, NO 1, Page. 70-76
Abstract
Genetic factors associated with susceptibility to papillary thyroid carcinoma (PTC) are not well known. We evaluated the association between single nucleotide polymorphisms (SNPs) of ataxia telangiectasia mutated (ATM) and the risk of PTC. A total of 437 histologically confirmed PTC cases and 184 cancer-free controls without thyroid nodules were recruited. Genotypes with respect to five ATM SNPs (rs189037, rs664677, rs373759, rs664143, and rs4585) were determined by the TaqMan assay, and odds ratios and 95% confidence intervals were obtained by logistic regression analysis. Linkage disequilibria and haplotypes were examined from the genotype data. When evaluated separately the genotype distributions of the five ATM SNPs were similar in the PTC cases and controls. Three ATM SNPs (rs373759, rs664143, and rs4585) were found to be in strong linkage disequilibrium (D=1.00, P˂0.001). When the three haplotypes (C-A-G), (T-G-T), and (C-G-T) of these three ATM SNP sites were analyzed, ATM haplotype (C-G-T) +/- was associated with a lower risk of PTC than ATM haplotype (C-G-T) -/- (P=0.03) after adjusting for age and gender. Our results suggest that genetic polymorphisms of ATM may play an important role in the development of thyroid cancer in the Korean population. Environ. Mol. Mutagen. 56:70-76, 2015. (c) 2014 Wiley Periodicals, Inc.
URI
http://hdl.handle.net/20.500.11754/21642http://onlinelibrary.wiley.com/doi/10.1002/em.21898/full
ISSN
0893-6692
DOI
10.1002/em.21898
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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