Alternations of Mean Diffusivity of Pedunculopontine Nucleus Pathway in Parkinson’s Disease Patients with Freezing of Gait

Title
Alternations of Mean Diffusivity of Pedunculopontine Nucleus Pathway in Parkinson’s Disease Patients with Freezing of Gait
Author
이종민
Keywords
Parkinson's; Freezing; Pedunculopontine; Diffusion tensor; Gait
Issue Date
2015-01
Publisher
ELSEVIER SCI LTD
Citation
PARKINSONISM & RELATED DISORDERS, v. 21, NO 1, Page. 12-17
Abstract
Background Although freezing of gait (FOG) is a common and disabling symptom in Parkinson's disease (PD), the underlying mechanism of FOG has not been clearly elucidated. Using analysis of diffusion tensor imaging (DTI), we investigated anatomic structures associated with FOG in PD patients. Methods We enrolled 33 controls and 42 PD patients (19 patients with FOG and 23 without FOG). DTI data were compared between PD patients and controls, and also between PD patients with and without FOG. Whole brain voxel-based analysis and regions of interest analysis in the pedunculopontine nucleus were used for DTI analysis. Results Compared with normal controls, PD patients showed microstructural changes in various subcortical structures (substantia nigra, globus pallidum and thalamus), frontal and insula cortex. PD patients with FOG demonstrated altered mean diffusivities in subcortical structures connected with pedunculopontine nucleus, such as basal ganglia, thalamus and cerebellum in voxel-based analysis. Using region of interest analysis of pedunculopontine nucleus, fractional anisotropy values were reduced and mean diffusivity values were increased bilaterally in PD patients with FOG. In correlation analysis, the fractional anisotropy value of the right pedunculopontine nucleus was moderately correlated with the severity of FOG. Conclusions Based on our results, microstructural changes of pedunculopontine nucleus and connected subcortical structures are closely related with FOG in PD patients.
URI
http://hdl.handle.net/20.500.11754/21621http://www.sciencedirect.com/science/article/pii/S1353802014003721
ISSN
1353-8020
DOI
10.1016/j.parkreldis.2014.10.003
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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