Surface-enhanced Raman scattering aptasensor for ultrasensitive trace analysis of bisphenol A

Title
Surface-enhanced Raman scattering aptasensor for ultrasensitive trace analysis of bisphenol A
Author
주재범
Keywords
Surface-enhanced Ramanscattering; Aptamer; Bisphenol A; Traceanalysis; Aptasensor
Issue Date
2015-01
Publisher
ELSEVIER ADVANCED TECHNOLOGY
Citation
BIOSENSORS & BIOELECTRONICS, v. 64, Page. 560-565
Abstract
Surface-enhanced Raman scattering (SERS)-based aptasensor platform, using double strand DNA-embedded Au/Ag core–shell nanoparticles, has been developed for the ultrasensitive detection of bisphenol A (BPA) in water. By combining optimally controlled Au/Ag core–shell nanoparticles with the selective BPA binding characteristics of DNA aptamers, a highly sensitive limit of detection (LOD) of 10 fM could be achieved for BPA-spiked tap water over a wide concentration range from 100 nM to 10 fM. This LOD is two or three orders of magnitude lower than that reported for other BPA sensing techniques, and also yields a detection limit that is 100–1000 times lower than the US EPA-defined Predicted No Effect Concentration (PNEC) values in potable water. Total detection time is estimated to be about 40 min including the reaction between aptamer and BPA (30 min) and detection (10 min). This sensing platform is also suitable for field applications since measurement can be performed under aqueous colloidal conditions.
URI
http://hdl.handle.net/20.500.11754/21523http://www.sciencedirect.com/science/article/pii/S095656631400774X
ISSN
0956-5663
DOI
10.1016/j.bios.2014.09.087
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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