The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share

Title
The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share
Authors
배상철배상철
Issue Date
2015-01
Publisher
OXFORD UNIV PRESS
Citation
HUMAN MOLECULAR GENETICS, v. 24, NO 2, Page. 582-596
Abstract
Exploiting genotyping, DNA sequencing, imputation and trans-ancestral mapping, we used Bayesian and frequentist approaches to model the IRF5-TNPO3 locus association, now implicated in two immunotherapies and seven autoimmune diseases. Specifically, in systemic lupus erythematosus (SLE), we resolved separate associations in the IRF5 promoter (all ancestries) and with an extended European haplotype. We captured 3230 IRF5-TNPO3 high-quality, common variants across 5 ethnicities in 8395 SLE cases and 7367 controls. The genetic effect from the IRF5 promoter can be explained by any one of four variants in 5.7 kb (P-value(meta) = 6 x 10(-49)OR = 1.38-1.97). The second genetic effect spanned an 85.5-kb, 24-variant haplotype that included the genes IRF5 and TNPO3(P-values(EU) = 10(-27)-10(-32), OR = 1.7-1.81). Many variants at the IRF5locus with previously assigned biological function are not members of either final credible set of potential causal variants identified herein. In addition to the known biologically functional variants, we demonstrated that the risk allele of rs4728142, a variant in the promoter among the lowest frequentist probability and highest Bayesian posterior probability, was correlated with IRF5expression and differentially binds the transcription factor ZBTB3. Our analytical strategy provides a novel framework for future studies aimed at dissecting etiological genetic effects. Finally, both SLE elements of the statistical model appear to operate in Sjogren's syndrome and systemic sclerosis whereas only the IRF5-TNPO3 gene-spanning haplotype is associated with primary biliary cirrhosis, demonstrating the nuance of similarity and difference in autoimmune disease risk mechanisms at IRF5-TNPO3.
URI
http://hdl.handle.net/20.500.11754/21362
ISSN
0964-6906
DOI
http://dx.doi.org/10.1093/hmg/ddu455
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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