Phloroglucinol suppresses metastatic ability of breast cancer cells by inhibition of epithelial-mesenchymal cell transition

Title
Phloroglucinol suppresses metastatic ability of breast cancer cells by inhibition of epithelial-mesenchymal cell transition
Authors
이수재
Keywords
phloroglucinol; cancer metastasis; basal type breast cancer cells; epithelial-mesenchymal transition; SLUG
Issue Date
2015-01
Publisher
WILEY-BLACKWELL
Citation
CANCER SCIENCE, v. 106, NO 1, Page. 94-101
Abstract
Metastasis is a challenging clinical problem and the primary cause of death in breast cancer patients. However, there is no therapeutic agent against metastasis of breast cancer cells. Here we report that phloroglucinol, a natural phlorotannin component of brown algae suppresses metastatic ability of breast cancer cells. Treatment with phloroglucinol effectively inhibited mesenchymal phenotypes of basal type breast cancer cells through downregulation of SLUG without causing a cytotoxic effect. Importantly, phloroglucinol decreased SLUG through inhibition of PI3K/AKT and RAS/RAF-1/ERK signaling. In agreement with in vitro data, phloroglucinol was also effective against in vivo metastasis of breast cancer cells, drastically suppressing their metastatic ability to lungs, and extending the survival time of mice. Collectively, our findings demonstrate a novel anticancer activity of phloroglucinol against metastasis of breast cancer cells, implicating its clinical relevance.
URI
http://hdl.handle.net/20.500.11754/21349http://onlinelibrary.wiley.com/doi/10.1111/cas.12562/full
ISSN
1347-9032
DOI
http://dx.doi.org/10.1111/cas.12562
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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