Activation of KRAS promotes the mesenchymal features of basal-type breast cancer

Title
Activation of KRAS promotes the mesenchymal features of basal-type breast cancer
Authors
이수재
Keywords
GENE-EXPRESSION; RAS ONCOGENES; SLUG; TRANSITIONS; PROGRESSION; MUTATIONS; PHENOTYPE; SURVIVAL; VARIANT
Issue Date
2015-01
Publisher
NATURE PUBLISHING GROUP
Citation
EXPERIMENTAL AND MOLECULAR MEDICINE, v. 47(1), Page. 1-9
Abstract
Basal-type breast cancers are among the most aggressive and deadly breast cancer subtypes, displaying a high metastatic ability associated with mesenchymal features. However, the molecular mechanisms underlying the maintenance of mesenchymal phenotypes of basal-type breast cancer cells remain obscure. Here, we report that KRAS is a critical regulator for the maintenance of mesenchymal features in basal-type breast cancer cells. KRAS is preferentially activated in basal-type breast cancer cells as compared with luminal type. By loss and gain of KRAS, we found that KRAS is necessary and sufficient for the maintenance of mesenchymal phenotypes and metastatic ability through SLUG expression. Taken together, this study demonstrates that KRAS is a critical regulator for the metastatic behavior associated with mesenchymal features of breast cancer cells, implicating a novel therapeutic target for basal-type breast cancer.
URI
http://hdl.handle.net/20.500.11754/21075http://www.nature.com/emm/journal/v47/n1/full/emm201499a.html
ISSN
1226-3613
DOI
http://dx.doi.org/10.1038/emm.2014.99
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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