The Effect of a Single Dose of Preemptive Pregabalin Administration With COX-2 Inhibitor: A Trial in Total Knee Arthroplasty
- The Effect of a Single Dose of Preemptive Pregabalin Administration With COX-2 Inhibitor: A Trial in Total Knee Arthroplasty
- knee; total knee arthroplasty; preemptive analgesia; acute postoperative pain; pregabalin
- Issue Date
- CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
- JOURNAL OF ARTHROPLASTY, v. 30, NO 1, Page. 38-42
- We sought to compare a group (Group L) (n = 21) of patients that underwent total knee arthroplasty
and received a single preoperative dose of pregabalin combined with a COX-2 inhibitor with a control group
(Group C) (n = 20) that only received a COX-2 inhibitor in terms of (1) acute postoperative pain intensity,
(2) analgesic consumption, and (3) functional recovery. Mean cumulative fentanyl consumption during the
first 48 hours was lower in Group L than in Group C (P b 0.05). The pain scores at rest were lower in Group L at
6 and 12 hours after surgery (P b 0.05). No significant intergroup difference was noted in functional recovery.
The addition of pregabalin led to an additive reduction in early postoperative pain and analgesic consumption.
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