The Effect of a Single Dose of Preemptive Pregabalin Administration With COX-2 Inhibitor: A Trial in Total Knee Arthroplasty

Title
The Effect of a Single Dose of Preemptive Pregabalin Administration With COX-2 Inhibitor: A Trial in Total Knee Arthroplasty
Authors
최충혁
Keywords
knee; total knee arthroplasty; preemptive analgesia; acute postoperative pain; pregabalin
Issue Date
2015-01
Publisher
CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
Citation
JOURNAL OF ARTHROPLASTY, v. 30, NO 1, Page. 38-42
Abstract
We sought to compare a group (Group L) (n = 21) of patients that underwent total knee arthroplasty and received a single preoperative dose of pregabalin combined with a COX-2 inhibitor with a control group (Group C) (n = 20) that only received a COX-2 inhibitor in terms of (1) acute postoperative pain intensity, (2) analgesic consumption, and (3) functional recovery. Mean cumulative fentanyl consumption during the first 48 hours was lower in Group L than in Group C (P b 0.05). The pain scores at rest were lower in Group L at 6 and 12 hours after surgery (P b 0.05). No significant intergroup difference was noted in functional recovery. The addition of pregabalin led to an additive reduction in early postoperative pain and analgesic consumption.
URI
http://hdl.handle.net/20.500.11754/21049http://www.sciencedirect.com/science/article/pii/S0883540314002356
ISSN
0883-5403
DOI
http://dx.doi.org/10.1016/j.arth.2014.04.004
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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