Apoptosis: a Janus bifrons in T-cell immunotherapy
- Title
- Apoptosis: a Janus bifrons in T-cell immunotherapy
- Author
- 이용구
- Keywords
- cytotoxicity; immunologic; immunotherapy; adoptive
- Issue Date
- 2023-04
- Publisher
- BMJ PUBLISHING GROUP
- Citation
- JOURNAL FOR IMMUNOTHERAPY OF CANCER, v. 11, NO 4
- Abstract
- Immunotherapy has revolutionized the treatment of cancer. In particular, immune checkpoint blockade, bispecific antibodies, and adoptive T-cell transfer have yielded unprecedented clinical results in hematological malignancies and solid cancers. While T cell-based immunotherapies have multiple mechanisms of action, their ultimate goal is achieving apoptosis of cancer cells. Unsurprisingly, apoptosis evasion is a key feature of cancer biology. Therefore, enhancing cancer cells' sensitivity to apoptosis represents a key strategy to improve clinical outcomes in cancer immunotherapy. Indeed, cancer cells are characterized by several intrinsic mechanisms to resist apoptosis, in addition to features to promote apoptosis in T cells and evade therapy. However, apoptosis is double-faced: when it occurs in T cells, it represents a critical mechanism of failure for immunotherapies. This review will summarize the recent efforts to enhance T cell-based immunotherapies by increasing apoptosis susceptibility in cancer cells and discuss the role of apoptosis in modulating the survival of cytotoxic T lymphocytes in the tumor microenvironment and potential strategies to overcome this issue.
- URI
- https://information.hanyang.ac.kr/#/eds/detail?an=000989727900004&dbId=edswschttps://repository.hanyang.ac.kr/handle/20.500.11754/189974
- ISSN
- 2051-1426
- DOI
- 10.1136/jitc-2022-005967
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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