자충 유래의 iscoumarin 성분의 antioxidant response element 유도 및 골격근 감소 개선 활성

Abstract

Eupolyphaga sinensis Walker, belonging to the family Corydiidae (Blattodea), is common in Southeast Asia. Due to its richness in nutrients, E. sinensis is usually used in traditional Oriental medicine as a basic component of anticoagulant and immune-enhancing remedies. Isolation from ethanol extract of E. sinensis yielded seven compounds, two isocoumarins (1 and 2) and four phenolic compounds 3-6. Their chemical structures were elucidated as (R)-6,8-dihydroxy-3,7-dimethyl-3,4-dihydroisochromen-1-one (monaschromone) (1), (R)-3-ethyl-6,8-dihydroxy-7-methyl-3,4-dihydroisochromen-1-one (2), 3methoxytyramine (3), hydroxyphenyl acetic acid (4), dihydroferulic acid (5), and protocatechuic acid (6), by spectroscopic anal-ysis. Among them, compounds 3-6 were first found in E. sinensis. Additionally, the two isocoumarins, 1 and 2, exhibited biological activity such as enhancing antioxidant response element and preventing dexamethasone-induced skeletal muscle atrophy in C2C12 myotubes. © 2023, Korean Society of Pharmacognosy. All rights reserved.;Eupolyphaga sinensis Walker, belonging to the family Corydiidae (Blattodea), is common in Southeast Asia. Due to its richness in nutrients, E. sinensis is usually used in traditional Oriental medicine as a basic component of anticoagulant and immune-enhancing remedies. Isolation from ethanol extract of E. sinensis yielded seven compounds, two isocoumarins (1 and 2) and four phenolic compounds 3-6. Their chemical structures were elucidated as (R)-6,8-dihydroxy-3,7-dimethyl-3,4-dihydroisochromen-1-one (monaschromone) (1), (R)-3-ethyl-6,8-dihydroxy-7-methyl-3,4-dihydroisochromen-1-one (2), 3-methoxytyramine (3), hydroxyphenyl acetic acid (4), dihydroferulic acid (5), and protocatechuic acid (6), by spectroscopic analysis. Among them, compounds 3-6 were first found in E. sinensis. Additionally, the two isocoumarins, 1 and 2, exhibited biological activity such as enhancing antioxidant response element and preventing dexamethasone-induced skeletal muscle atrophy in C2C12 myotubes.