Swimming exercise stimulates neuro-genesis in the subventricular zone via increase in synapsin i and nerve growth factor levels
- Title
- Swimming exercise stimulates neuro-genesis in the subventricular zone via increase in synapsin i and nerve growth factor levels
- Author
- 박범영
- Keywords
- physical training; progenitor cells; olfactory bulb; neurotrophic factors; brain; rats
- Issue Date
- 2014-00
- Publisher
- Instytut Sportu/Institute of Sport
- Citation
- Biology of Sport, v. 31, NO. 4, Page. 309-314
- Abstract
- In this study, we investigated the effects of 8-weeks of swimming exercise on neurogenesis in the subventricular zone (SVZ) and on the levels of nerve growth factor (NGF) and synapsin I protein in the olfactory bulb (OB) of adult rats at a series of relevant time points (2 days, 1 week, 2 weeks, 4 weeks, 3 months, and 6 months). Ninety-six male Sprague Dawley rats were divided into 2 groups: (1) a control group (COG; n = 48, n = 8 for each time point) and (2) a swimming exercise group (SEG; total n = 48; n = 8 for each time point). SEG performed swimming exercise for 5 days per week over a period of 8 weeks. We found that the number of 5-bromo-2'-deoxyuridine-5'-monophosphate (BrdU)- and doublecortin (DCX)-positive cells was significantly higher in SEG than in COG at all time points (Day 2, Week 1, Week 2, Week 4, Month 3, and Month 6; p < 0.001). Furthermore, NGF and synapsin I protein levels were significantly higher in SEG on Day 2, and Weeks 1, 2, and 4 than in COG (p < 0.05 for each time point). Our findings suggest that regular swimming exercise in adult rats increases neurogenesis, neuronal survival, and neuronal maintenance in the SVZ; furthermore, swimming exercise increases the levels of NGF and synapsin I in the OB.
- URI
- https://www.proquest.com/docview/2447236888?accountid=11283https://repository.hanyang.ac.kr/handle/20.500.11754/186462
- ISSN
- 0860-021X;2083-1862
- DOI
- 10.5604/20831862.1132130
- Appears in Collections:
- COLLEGE OF SPORTS AND ARTS[E](예체능대학) > ETC
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