Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이학준 | - |
dc.date.accessioned | 2023-07-20T01:46:27Z | - |
dc.date.available | 2023-07-20T01:46:27Z | - |
dc.date.issued | 2008-06 | - |
dc.identifier.citation | Synthesis, NO. 12, Page. 1841-1844 | - |
dc.identifier.issn | 0039-7881;1437-210X | - |
dc.identifier.uri | https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-2008-1067084 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/183989 | - |
dc.description.abstract | We have developed a new and straightforward synthesis of racemic tolterodine [NN-diisopropyl-3-(2-hydroxy-5-methyl-phenyl)-3-phenylpropanamine]. The synthesis involves selective nosylation on the primary alcohol of 1-phenylpropane-1,3-diol using 4-nitrobenzenesulfonyl chloride, subsequent diisopropylamine substitution, and Friedel-Crafts alkylation using aqueous perchloric acid. | - |
dc.description.sponsorship | National Research Foundation of Korea [과C6A2605] | - |
dc.language | en | - |
dc.publisher | Georg Thieme Verlag | - |
dc.subject | drugs | - |
dc.subject | diol | - |
dc.subject | selective sulfonation | - |
dc.subject | nucleophilic substitution | - |
dc.subject | Friedel-Crafts alkylation | - |
dc.title | Selective nosylation of 1-phenylpropane-1,3-diol and perchloric acid mediated Friedel-Crafts alkylation: Key steps for the new and straightforward synthesis of tolterodine | - |
dc.type | Article | - |
dc.relation.no | 12 | - |
dc.identifier.doi | 10.1055/s-2008-1067084 | - |
dc.relation.page | 1841-1844 | - |
dc.relation.journal | Synthesis | - |
dc.contributor.googleauthor | De Castro, Kathlia A. | - |
dc.contributor.googleauthor | Rhee, Hakjune | - |
dc.sector.campus | E | - |
dc.sector.daehak | 과학기술융합대학 | - |
dc.sector.department | 화학분자공학과 | - |
dc.identifier.pid | hrhee | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.