Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이학준 | - |
dc.date.accessioned | 2023-07-20T01:41:12Z | - |
dc.date.available | 2023-07-20T01:41:12Z | - |
dc.date.issued | 2010-11 | - |
dc.identifier.citation | Bioorganic and Medicinal Chemistry, v. 18, NO. 22, Page. 7724-7730 | - |
dc.identifier.issn | 0968-0896;1464-3391 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0968089610005729?via%3Dihub | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/183980 | - |
dc.description.abstract | Fluorescence probes that can detect A beta (beta-amyloid peptide) plaque are important tools for diagnosis of Alzheimer's disease (AD), and 4-N-methylamino-4'-hydroxystilbene (SB-13) is one of the promising candidate molecules. We report here the synthesis of SB-13 derivatives that consist of various electron donating/withdrawing moieties and distinct size of N-substituents. The synthesized compounds were screened for detection of A beta 40 fibrils in vitro. Four compounds exhibited more than sixfold intensity increase, and they were further analyzed for detail bindings and A beta plaque imaging. Among these molecules, compound 42 meets two critical requirements for imaging agent; high fluorescence responsiveness and strong binding affinity. This compound showed more than 25-fold increase with the dissociation constant of 1.13 +/- 0.37 mu M. In AD mouse brain tissue, 42 selectively stained A beta plaque, more specifically peripheral regions of A beta plaque. This finding demonstrated its potential use as brain-imaging agents for AD studies. (C) 2010 Elsevier Ltd. All rights reserved. | - |
dc.description.sponsorship | This study was supported by Korea Science and Engineering Foundation (KOSEF) (M20702010001-07N0201-00110) and Ministry of Science and Technology (MOST), Republic of Korea, through its National Nuclear Technology Program. Also this work was supported by and intramural funding from A*STAR Biomedical Research Council and National University of Singapore Young Investigator Award (R-143-000-353-123). J.-S. Lee thanks for the generous support of the POSCO TJ Park Foundation (TJ Park Bessemer Science Fellowship). | - |
dc.language | en | - |
dc.publisher | Pergamon Press Ltd. | - |
dc.subject | Alzheimer's disease (AD) | - |
dc.subject | beta-Amyloid peptide (A beta) | - |
dc.subject | Fluorescence imaging probe | - |
dc.title | Synthesis and evaluation of stilbene derivatives as a potential imaging agent of amyloid plaques | - |
dc.type | Article | - |
dc.relation.no | 22 | - |
dc.relation.volume | 18 | - |
dc.identifier.doi | 10.1016/j.bmc.2010.06.044 | - |
dc.relation.page | 7724-7730 | - |
dc.relation.journal | Bioorganic and Medicinal Chemistry | - |
dc.contributor.googleauthor | Hong, Myeng Chan | - |
dc.contributor.googleauthor | Kim, Yun Kyung | - |
dc.contributor.googleauthor | Choi, Jae Yong | - |
dc.contributor.googleauthor | Yang, Si Qiang | - |
dc.contributor.googleauthor | Rhee, Hakjune | - |
dc.contributor.googleauthor | Ryu, Young Hoon | - |
dc.contributor.googleauthor | Choi, Tae Hyun | - |
dc.contributor.googleauthor | Cheon, Gi Jeong | - |
dc.contributor.googleauthor | Il An, Gwang | - |
dc.contributor.googleauthor | Kim, Hye Yun | - |
dc.contributor.googleauthor | Kim, Youngsoo | - |
dc.contributor.googleauthor | Kim, Dong Jin | - |
dc.contributor.googleauthor | Lee, Jun-Seok | - |
dc.contributor.googleauthor | Chang, Young-Tae | - |
dc.contributor.googleauthor | Lee, Kyo Chul | - |
dc.sector.campus | E | - |
dc.sector.daehak | 과학기술융합대학 | - |
dc.sector.department | 화학분자공학과 | - |
dc.identifier.pid | hrhee | - |
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