Synthesis of 1,3,5-trisubstituted-1,2,4-triazoles by microwave-assisted N-acylation of amide derivatives and the consecutive reaction with hydrazine hydrochlorides
- Title
- Synthesis of 1,3,5-trisubstituted-1,2,4-triazoles by microwave-assisted N-acylation of amide derivatives and the consecutive reaction with hydrazine hydrochlorides
- Author
- 이학준
- Keywords
- Microwave-assisted reaction; 1,2,4-Triazole; N-Acylation reaction; Cyclization reaction; One-pot sequential reaction
- Issue Date
- 2012-02
- Publisher
- Pergamon Press Ltd.
- Citation
- Tetrahedron, v. 68, NO. 8, Page. 2045-2051
- Abstract
- Facile and efficient procedures for the N-acylation reaction of amide derivatives with various acid anhydrides and the cyclization reaction of N-acylated amide derivatives with various hydrazine hydrochlorides were described. The reactions were carried out under microwave irradiation to give products in good yields in a few minutes. The synthesis of 1,3,5-trisubstituted-1,2,4-triazoles from benzamides can also be accomplished in a simple one-pot sequential reaction. (C) 2012 Elsevier Ltd. All rights reserved.
- URI
- https://www.sciencedirect.com/science/article/pii/S0040402012000166?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/183976
- ISSN
- 0040-4020
- DOI
- 10.1016/j.tet.2012.01.003
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > CHEMICAL AND MOLECULAR ENGINEERING(화학분자공학과) > Articles
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