Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 임동우 | - |
dc.date.accessioned | 2023-07-17T01:51:36Z | - |
dc.date.available | 2023-07-17T01:51:36Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.citation | SENSORS AND ACTUATORS B-CHEMICAL, v. 255, Page. 183-192 | - |
dc.identifier.issn | 0925-4005 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0925400517313552?via%3Dihub | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/183855 | - |
dc.description.abstract | Surface-enhanced Raman scattering (SERS) has been of great interest to advance sensitive optical biosensors. Clustered metallic nanoparticles as SERS nanoprobes are important to detect specific biomolecules with ultra-sensitivity. We report herein that the cluster formation of gold nanoparticles (GNPs) was induced by nanoscale graphene oxides (NGOs) with 120 nm to develop a new class of SERS nanotags for biosensing. The GNPs with 4-mercaptopyridine as a Raman reporter were modified with 1-pyrenemethylamine to introduce hydrophobic moieties on the surfaces and were complexed with NGOs via noncovalent interactions of pi-pi stacking and van der Waals interactions, resulting in the formation of NGO-GNP clusters (NGO-GNPCs). The NGO-GNPCs increased the SERS signal 3- to 4-fold higher than that of the individual GNPs due to enhancement of the electromagnetic field at the interstices of the GNPs. As a proof of concept, the NGO-GNPCs as SERS nanoprobes and magnetic beads (MBs) were developed to detect immunoglobulin G (IgG). Sandwich-type immunocomplexes of the NGO-GNPCs, IgG, and MBs were formed, representing a linear correlation between Raman intensity and IgG concentration, and a limit of detection of 0.6 pM. It suggests that the NGO-GNPCs as SERS nanoprobes could open a new avenue for highly sensitive SERS-based biosensing. (C) 2017 Elsevier B.V. All rights reserved. | - |
dc.language | en | - |
dc.publisher | ELSEVIER SCIENCE SA | - |
dc.subject | Nanoscale graphene oxide | - |
dc.subject | Metallic nanoparticles | - |
dc.subject | Clusters | - |
dc.subject | Surface enhanced Raman scattering | - |
dc.subject | IgG detection | - |
dc.title | Nanoscale graphene oxide-induced metallic nanoparticle clustering for surface-enhanced Raman scattering-based IgG detection | - |
dc.type | Article | - |
dc.relation.volume | 255 | - |
dc.identifier.doi | 10.1016/j.snb.2017.07.140 | - |
dc.relation.page | 183-192 | - |
dc.relation.journal | SENSORS AND ACTUATORS B-CHEMICAL | - |
dc.contributor.googleauthor | Ali, Ahmed | - |
dc.contributor.googleauthor | Hwang, Eun Young | - |
dc.contributor.googleauthor | Choo, Jaebum | - |
dc.contributor.googleauthor | Lim, Dong Woo | - |
dc.sector.campus | E | - |
dc.sector.daehak | 공학대학 | - |
dc.sector.department | 생명나노공학과 | - |
dc.identifier.pid | dlim | - |
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