Evaluation of Metabolic Stability of Kinsenoside, an Antidiabetic Candidate, in Rat and Human Liver Microsomes
- Title
- Evaluation of Metabolic Stability of Kinsenoside, an Antidiabetic Candidate, in Rat and Human Liver Microsomes
- Author
- 유혜현
- Keywords
- kinsenoside; stability; liver microsomes
- Issue Date
- 2015-06
- Publisher
- 사단법인 한국질량분석학회
- Citation
- Mass Spectrometry Letters, v. 6, NO. 2, Page. 48.0-51.0
- Abstract
- Kinsenoside is a principle bioactive compound of Anoectochilus formosanus. It exhibits various pharmacological effects such as antihyperglycemic, antioxidant, anti-inflammatory, immunostimulating, and hepatoprotective activities and has recently been developed as an antidiabetic drug candidate. In this study, as part of an in vitro pharmacokinetic study, the stability of kinsenoside in rat and human liver microsomes was evaluated. Kinsenoside was found to have good metabolic stability in both rat and human liver microsomes. These results will provide useful information for further in vivo pharmacokinetic and metabolism studies.
- URI
- http://koreascience.or.kr/article/JAKO201530848399266.pagehttps://repository.hanyang.ac.kr/handle/20.500.11754/182347
- ISSN
- 2233-4203;2093-8950
- DOI
- 10.5478/MSL.2015.6.2.48
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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