Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2023-06-23T02:14:59Z | - |
dc.date.available | 2023-06-23T02:14:59Z | - |
dc.date.issued | 2018-04 | - |
dc.identifier.citation | NPG ASIA MATERIALS, v. 10, Page. 197.0-216.0 | - |
dc.identifier.issn | 1884-4049;1884-4057 | - |
dc.identifier.uri | https://www.nature.com/articles/s41427-018-0034-5 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/182323 | - |
dc.description.abstract | Multimodal therapeutic agents based on novel nanomaterials for multidrug resistance have attracted increasing attention in cancer therapy. In this study, we describe the construction of a programmed mesoporous silica-capped gold nanorod covered with nano-selenium overcoat (Se@Au@mSiO(2)) nanoparticles as a multifunctional nanoplatform to incorporate materials with specific chemotherapeutic, chemoprevention, and photoablation/hyperthermia functions that collectively contribute to enhance anticancer efficacy in multidrug-resistant breast cancer. The triple-combination-based nanosized Se@Au@mSiO(2)/DOX effectively accumulates in the tumor and the release of the therapeutic cargo could be remotely manipulated by mild near-infrared (NIR) irradiation. Se@Au@mSiO(2)/DOX notably enhances the cell killing effect through induction of cell apoptosis. In addition, Se@Au@mSiO(2)/DOX inhibits tumor cell growth through cell cycle arrest and induction of apoptosis via suppression of the Src/FAK/AKT signaling pathways. Synergistic Se-photothermal-chemotherapy combination exhibits significant tumor growth suppression and delayed tumor progression in vivo. Immunohistochemistry analysis shows elevated numbers of caspase-3 and PARP-immunolabeled cells and decreased Ki-67 + and CD31 + cancer cells in the tumor mass. No noticeable signs of organ damage or toxicity are observed after treatment with Se@Au@mSiO2/DOX (NIR+), which is further supported by hematology and biochemical analyses. Thus, Se@Au@mSiO2/DOX has potential for the clinical treatment of metastatic breast cancers with little or no adverse effects. | - |
dc.description.sponsorship | the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2015R1A2A2A01004118, 2015R1A2A2A04004806); the Medical Research Center Program (2015R1A5A2009124) through the NRF funded by MSIP. | - |
dc.language | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | POLYELECTROLYTE COMPLEX MICELLES | - |
dc.subject | HYBRID NANOPARTICLES | - |
dc.subject | GOLD NANOPARTICLES | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | CHEMOTHERAPY | - |
dc.subject | DOXORUBICIN | - |
dc.subject | CELLS | - |
dc.subject | COMBINATION | - |
dc.subject | EFFICACY | - |
dc.subject | SIZE | - |
dc.title | Multimodal selenium nanoshell-capped Au@mSiO(2) nanoplatform for NIR-responsive chemo-photothermal therapy against metastatic breast cancer | - |
dc.type | Article | - |
dc.relation.volume | 10 | - |
dc.identifier.doi | 10.1038/s41427-018-0034-5 | - |
dc.relation.page | 197.0-216.0 | - |
dc.relation.journal | NPG ASIA MATERIALS | - |
dc.contributor.googleauthor | Ramasamy, Thiruganesh | - |
dc.contributor.googleauthor | Ruttala, Hima Bindu | - |
dc.contributor.googleauthor | Sundaramoorthy, Pasupathi | - |
dc.contributor.googleauthor | Poudel, Bijay Kumar | - |
dc.contributor.googleauthor | Youn, Yu Seok | - |
dc.contributor.googleauthor | Ku, Sae Kwang | - |
dc.contributor.googleauthor | Choi, Han-Gon | - |
dc.contributor.googleauthor | Yong, Chul Soon | - |
dc.contributor.googleauthor | Kim, Jong Oh | - |
dc.sector.campus | E | - |
dc.sector.daehak | 약학대학 | - |
dc.sector.department | 약학과 | - |
dc.identifier.pid | hangon | - |
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