Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남태규 | - |
dc.date.accessioned | 2023-04-25T04:17:44Z | - |
dc.date.available | 2023-04-25T04:17:44Z | - |
dc.date.issued | 2016-05 | - |
dc.identifier.citation | MOLECULES, v. 21.0, NO. 5, article no. 594, Page. 1-11 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://www.mdpi.com/1420-3049/21/5/594 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/179306 | - |
dc.description.abstract | Glutamate is the major excitatory neurotransmitter in the brain. It can cause neuronal cell damage in the context of oxidative stress. BJ-1201 is a derivative of the compound aminopyridinol, which is known for its antioxidant activity. In this study, we examined the effect of BJ-1201, a 6-(diphenylamino)-2,4,5-trimethylpyridin-3-ol compound, on neuroprotection in HT22 cells. Our data showed that BJ-1201 can protect HT22 cells against glutamate-induced cell cytotoxicity. In addition, BJ-1201 upregulated heme oxygenase-1 (HO-1) to levels comparable to those of the CoPP-treated group. BJ-1201 treatment induced phosphorylation of JNK, but not p38-MAPK or ERK. It also increased the signal in the reporter assay based on beta-galactosidase activity driven by the nuclear transcription factor erythroid-2 related factor 2 (Nrf2) promoter harboring antioxidant response elements (AREs) and induced the translocation of Nrf2. These results demonstrate that BJ-1201 may be a good therapeutic platform against neurodegenerative diseases induced by oxidative stress. | - |
dc.description.sponsorship | This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. NRF-2016R1A6A1A03011325). | - |
dc.language | en | - |
dc.publisher | MDPI AG | - |
dc.subject | aminopyridinol compound BJ-1201 | - |
dc.subject | neuroprotection | - |
dc.subject | aminopyridinol HT22 | - |
dc.subject | heme oxygenase-1 | - |
dc.subject | nuclear transcription factor erythroid-2 related factor 2 | - |
dc.title | RETRACTED: The Aminopyridinol Derivative BJ-1201 Protects Murine Hippocampal Cells against Glutamate-Induced Neurotoxicity via Heme Oxygenase-1 (Retracted Article. See vol 21, Art no 1463, 2016) | - |
dc.type | Article | - |
dc.relation.no | 5 | - |
dc.relation.volume | 21.0 | - |
dc.identifier.doi | 10.3390/molecules21050594 | - |
dc.relation.page | 1-11 | - |
dc.relation.journal | MOLECULES | - |
dc.contributor.googleauthor | Lee, Dong-Sung | - |
dc.contributor.googleauthor | Nam, Tae-Gyu | - |
dc.contributor.googleauthor | Jeong, Byeong-Seon | - |
dc.contributor.googleauthor | Jeong, Gil-Saeng | - |
dc.sector.campus | E | - |
dc.sector.daehak | 약학대학 | - |
dc.sector.department | 약학과 | - |
dc.identifier.pid | tnam | - |
dc.identifier.article | 594 | - |
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