Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안주홍 | - |
dc.date.accessioned | 2022-12-05T01:26:11Z | - |
dc.date.available | 2022-12-05T01:26:11Z | - |
dc.date.issued | 2021-03 | - |
dc.identifier.citation | MOLECULES AND CELLS, v. 44, NO. 3, Page. 160-167 | en_US |
dc.identifier.issn | 1016-8478;0219-1032 | en_US |
dc.identifier.uri | https://www.molcells.org/journal/view.html?doi=10.14348/molcells.2021.2236#right_tools | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/177896 | - |
dc.description.abstract | The determinant factors of an organism’s size during animal development have been explored from various angles but remain partially understood. In Caenorhabditis elegans, many genes affecting cuticle structure, cell growth, and proliferation have been identified to regulate the worm’s overall morphology, including body size. While various mutations in those genes directly result in changes in the morphological phenotypes, there is still a need for established, clear, and distinct standards to determine the apparent abnormality in a worm’s size and shape. In this study, we measured the body length, body width, terminal bulb length, and head size of mutant worms with reported Dumpy (Dpy), Small (Sma) or Long (Lon) phenotypes by plotting and comparing their respective ratios of various parameters. These results show that the Sma phenotypes are proportionally smaller overall with mild stoutness, and Dpy phenotypes are significantly stouter and have disproportionally small head size. This study provides a standard platform for determining morphological phenotypes designating and annotating mutants that exhibit body shape variations, defining the morphological phenotype of previously unexamined mutants. | en_US |
dc.description.sponsorship | Some strains are provided by the CGC, funded by NIH Office of Research Infrastructure Programs (P40 OD010440) or National Bioresource Project Japan. This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2018R1A2A3074987 to S.K.L.; 2018R1D1A1B07046893 to J.A.) and Research Grant from Hanyang University (201500000001686). | en_US |
dc.language | en | en_US |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | en_US |
dc.source | 79841_안주홍.pdf | - |
dc.subject | Caenorhabditis elegans | en_US |
dc.subject | K-means clustering | en_US |
dc.subject | long | en_US |
dc.subject | small | en_US |
dc.subject | dumpy | en_US |
dc.title | Morphological Characterization of small, dumpy, and long Phenotypes in Caenorhabditis elegans | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 44 | - |
dc.identifier.doi | 10.14348/molcells.2021.2236 | en_US |
dc.relation.page | 160-167 | - |
dc.relation.journal | MOLECULES AND CELLS | - |
dc.contributor.googleauthor | Cho, Joshua Young | - |
dc.contributor.googleauthor | Choi, Tae-Woo | - |
dc.contributor.googleauthor | KIm, Seung Hyun | - |
dc.contributor.googleauthor | Ahnn, Joohong | - |
dc.contributor.googleauthor | Lee, Sun-Kyung | - |
dc.sector.campus | S | - |
dc.sector.daehak | 자연과학대학 | - |
dc.sector.department | 생명과학과 | - |
dc.identifier.pid | joohong | - |
dc.identifier.orcid | https://orcid.org/0000-0003-2229-3580 | - |
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