Chemical Communications, v. 48, NO. 4, Page. 588-590
Abstract
Cleavage agents showed cleavage yields as much as 9-14%, which does not sufficiently support the agents' protection of beta-cells from the cytotoxicity of h-IAPP. INS-1 cell tests were carried out to better understand the potential of using these cleavage agents as drug candidates. This study provides the firm basis for clinical applicability of these cleavage agents.