Deoxycholate-Based Glycosides (DCGs) for Membrane Protein Stabilisation
- Title
- Deoxycholate-Based Glycosides (DCGs) for Membrane Protein Stabilisation
- Author
- 채필석
- Keywords
- amphiphiles; deoxycholate; membrane proteins; molecular design; stabilization
- Issue Date
- 2015-07
- Publisher
- John Wiley & Sons Ltd.
- Citation
- ChemBioChem, v. 16, NO. 10, Page. 1454-1459
- Abstract
- Detergents are an absolute requirement for studying the structure of membrane proteins. However, many conventional detergents fail to stabilise denaturation-sensitive membrane proteins, such as eukaryotic proteins and membrane protein complexes. New amphipathic agents with enhanced efficacy in stabilising membrane proteins will be helpful in overcoming the barriers to studying membrane protein structures. We have prepared a number of deoxycholate-based amphiphiles with carbohydrate head groups, designated deoxycholate-based glycosides (DCGs). These DCGs are the hydrophilic variants of previously reported deoxycholate-based N-oxides (DCAOs). Membrane proteins in these agents, particularly the branched diglucoside-bearing amphiphiles DCG-1 and DCG-2, displayed favourable behaviour compared to previously reported parent compounds (DCAOs) and conventional detergents (LDAO and DDM). Given their excellent properties, these agents should have significant potential for membrane protein studies.
- URI
- https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.201500151https://repository.hanyang.ac.kr/handle/20.500.11754/176133
- ISSN
- 1439-4227;1439-7633
- DOI
- 10.1002/cbic.201500151
- Appears in Collections:
- COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > BIONANO ENGINEERING(생명나노공학과) > Articles
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