Molecular evidence for suppression of swimming behavior and reproduction in the estuarine rotifer Brachionus koreanus in response to COVID-19 disinfectants
- Title
- Molecular evidence for suppression of swimming behavior and reproduction in the estuarine rotifer Brachionus koreanus in response to COVID-19 disinfectants
- Author
- 원은지
- Keywords
- Antimicrobials; RNA sequencing; Ingenuity pathway analysis; Estuarine rotifer; Brachionus koreanus
- Issue Date
- 2022-02
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Citation
- In Marine Pollution Bulletin February 2022 175
- Abstract
- The increased use of disinfectants due to the spread of the novel coronavirus infection (e.g. COVID-19) has caused
burden in the environment but knowledge on its ecotoxicological impact on the estuary environment is limited.
Here we report in vivo and molecular endpoints that we used to assess the effects of chloroxylenol (PCMX) and
benzalkonium chloride (BAC), which are ingredients in liquid handwash, dish soap products, and sanitizers used
by consumers and healthcare workers on the estuarine rotifer Brachionus koreanus. PCMX and BAC significantly
affected the life table parameters of B. koreanus. These chemicals modulated the activities of antioxidant enzymes
such as superoxide dismutase and catalase and increased reactive oxygen species even at low concentrations.
Also, PCMX and BAC caused alterations in the swimming speed and rotation rate of B. koreanus. Furthermore, an
RNA-seq-based ingenuity pathway analysis showed that PCMX affected several signaling pathways, allowing us
to predict that a low concentration of PCMX will have deleterious effects on B. koreanus. The neurotoxic and
mitochondrial dysfunction event scenario induced by PCMX reflects the underlying molecular mechanisms by
which PCMX produces outcomes deleterious to aquatic organisms.
- URI
- https://www.sciencedirect.com/science/article/pii/S0025326X22000789https://repository.hanyang.ac.kr/handle/20.500.11754/171057
- ISSN
- 0025-326X
- DOI
- 10.1016/j.marpolbul.2022.113396
- Appears in Collections:
- OFFICE OF ACADEMIC AFFAIRS[E](교무처) > Center for Creative Convergence Education(창의융합교육원) > Articles
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