Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남진우 | - |
dc.date.accessioned | 2022-05-10T06:34:19Z | - |
dc.date.available | 2022-05-10T06:34:19Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v. 11, no. 1, article no. 4483 | en_US |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://www.nature.com/articles/s41467-020-18135-y | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/170731 | - |
dc.description.abstract | The Drosophila lymph gland, the larval hematopoietic organ comprised of prohemocytes and mature hemocytes, has been a valuable model for understanding mechanisms underlying hematopoiesis and immunity. Three types of mature hemocytes have been characterized in the lymph gland: plasmatocytes, lamellocytes, and crystal cells, which are analogous to vertebrate myeloid cells, yet molecular underpinnings of the lymph gland hemocytes have been less investigated. Here, we use single-cell RNA sequencing to comprehensively analyze heterogeneity of developing hemocytes in the lymph gland, and discover previously undescribed hemocyte types including adipohemocytes, stem-like prohemocytes, and intermediate prohemocytes. Additionally, we identify the developmental trajectory of hemocytes during normal development as well as the emergence of the lamellocyte lineage following active cellular immunity caused by wasp infestation. Finally, we establish similarities and differences between embryonically derived- and larval lymph gland hemocytes. Altogether, our study provides detailed insights into the hemocyte development and cellular immune responses at single-cell resolution. | en_US |
dc.description.sponsorship | The authors thank Dr. Greg S. Suh and all members of the Shim and the BIG labs for helpful discussions. The authors acknowledge the Bloomington, VDRC, DGRC, NIG, and KDRC Drosophila stock centers and the DSHB hybridoma bank. The authors thank the following individuals for stocks and reagents: Drs. C. Evans, U. Banerjee, S. Sinenko, M. Zeidler, M. Crozatier, K. Brueckner, Nambu JR, A. Brand, and F. Schweisguth. This work was supported by the Samsung Science and Technology Foundation under Project Number SSTF-BA1701-15 to J.S. and by the National Research Foundation (NRF) funded by the Ministry of Science and ICT under Project Numbers 2020R1A4A1018398 and 2018R1A2B2003782 to J.N., and 2016R1A5A2008630 to S.J.M. N.P. is an Investigator of the Howard Hughes Medical Institute. | en_US |
dc.language.iso | en | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | PROGENITOR MAINTENANCE | en_US |
dc.subject | LYMPH-GLAND | en_US |
dc.subject | HEMATOPOIETIC PROGENITORS | en_US |
dc.subject | HEMOCYTE LINEAGES | en_US |
dc.subject | IMMUNE-RESPONSE | en_US |
dc.subject | STEM-CELLS | en_US |
dc.subject | MODEL | en_US |
dc.subject | PROLIFERATION | en_US |
dc.subject | PHAGOCYTOSIS | en_US |
dc.subject | SPECIFICATION | en_US |
dc.title | Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila | en_US |
dc.type | Article | en_US |
dc.relation.volume | 11 | - |
dc.identifier.doi | 10.1038/s41467-020-18135-y | - |
dc.relation.page | 4483-4495 | - |
dc.relation.journal | NATURE COMMUNICATIONS | - |
dc.contributor.googleauthor | Cho, Bumsik | - |
dc.contributor.googleauthor | Yoon, Sang-Ho | - |
dc.contributor.googleauthor | Lee, Daewon | - |
dc.contributor.googleauthor | Koranteng, Ferdinand | - |
dc.contributor.googleauthor | Tattikota, Sudhir Gopal | - |
dc.contributor.googleauthor | Cha, Nuri | - |
dc.contributor.googleauthor | Shin, Mingyu | - |
dc.contributor.googleauthor | Do, Hobin | - |
dc.contributor.googleauthor | Hu, Yanhui | - |
dc.contributor.googleauthor | Nam, Jin-Wu | - |
dc.relation.code | 2020046258 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | jwnam | - |
dc.identifier.orcid | https://orcid.org/0000-0003-0047-3687 | - |
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