Nanovaccines silencing IL-10 production at priming phase for boosting immune responses to melanoma
- Title
- Nanovaccines silencing IL-10 production at priming phase for boosting immune responses to melanoma
- Author
- 최한곤
- Keywords
- Cancer vaccines; Dendritic cells; IL-10; Immunotherapy; Melanoma
- Issue Date
- 2021-11
- Publisher
- ELSEVIER
- Citation
- JOURNAL OF CONTROLLED RELEASE, v. 338, Page. 211-223
- Abstract
- Despite the significant efforts in developing cancer vaccines, there are still numerous challenges that need to be
addressed to ensure their clinical efficacy. Herein, a lymphatic dendritic cell (DC)-targeted artificial nanovaccine
mimicking tumor cell membrane (ATM-NV) is developed to boost effector immune response and control
immunosuppression simultaneously. The NVs are formulated with lipids, tumor cell membrane proteins, imi-
quimod (IMQ), and IL-10 siRNA. IL-10 siRNA is incorporated to inhibit the secretion of IL-10, an immunosup-
pressive cytokine, of maturated DCs upon IMQ. To enhance the DC targeting ability, the nanovaccine surface was
non-covalently conjugated with the anti-CD205 antibody. The IMQ and IL-10 siRNA co-loaded, CD205 receptor-
targeted artificial tumor membrane NVs (IMQ/siR@ATM-NVs) efficiently migrate to the tumor-draining lymph
node and target DCs. Furthermore, immunization with IMQ/siR@ATM-NVs reduces the production of IL-10 and
increases Th1-driven antitumor immunity resulted in a great tumor inhibition efficacy. Our results suggest a
potential strategy to promote the vaccination's antitumor efficacy by blocking the intrinsic negative regulators in
DCs.
- URI
- https://www.sciencedirect.com/science/article/pii/S0168365921004375https://repository.hanyang.ac.kr/handle/20.500.11754/169829
- ISSN
- 0168-3659
- DOI
- 10.1016/j.jconrel.2021.08.031
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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