PICOT attenuates cardiac hypertrophy by disrupting calcineurin-NFAT signaling

Abstract

The article details a study on the role of the protein kinase C interacting cousin of thioredoxin (PICOT) in cardiac hypertrophy. The authors hypothesize that PICOT directly interacts with muscle LIM protein (MLP) via its carboxyl-terminal half and that PICOT may affect calcineurin-nuclear factor of activated T cells (NFAT) signaling through its interaction with MLP. They conclude that PICOT inhibits cardiac hypertrophy largely by negatively regulating calcineurin-NFAT signaling via disruption of the MLP-calcineurin interaction.