Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2021-12-23T01:44:10Z | - |
dc.date.available | 2021-12-23T01:44:10Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.citation | PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, v. 26, No. 5, Page. 576-581 | en_US |
dc.identifier.issn | 1083-7450 | - |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/10837450.2021.1903036 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/166807 | - |
dc.description.abstract | The objective of this study was to develop a novel acetaminophen and tramadol hydrochloride-loaded soft capsule (ATSC) with enhanced bioavailability of tramadol. The ATSC was manufactured in a pilot-scale batch size with the capsule contents composed of tramadol, acetaminophen, PEG 400 and Capmul MCM at a weight ratio of 37.5:325:177.5:30. Moreover, its dissolution, stability and pharmacokinetics in beagle dogs were carried out compared to commercial tablet. The dissolved amounts of acetaminophen from the ATSC and commercial tablet were not significantly different. However, compared to the latter, the former had significantly higher dissolution rate of tramadol at the initial times. In beagle dogs, the ATSC provided no significant difference in plasma concentrations and AUC of acetaminophen than did the commercial tablet; however, it significantly improved those of tramadol compared to the other, indicating the enhanced oral bioavailability of tramadol. Compared to the commercial tablet, the ATSC had a larger AUC value for tramadol (55.27 ± 11.06 vs. 92.62 ± 21.52 h·ng/ml). In the accelerated long-term stability, the ATSC offered higher than 96% drug content of acetaminophen and tramadol, suggesting that it was stable for at least six months. Therefore, this ATSC would be a recommendable candidate with enhanced oral bioavailability and excellent stability. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | TAYLOR & FRANCIS LTD | en_US |
dc.subject | Acetaminophen | en_US |
dc.subject | Capmul MCM | en_US |
dc.subject | oral bioavailability | en_US |
dc.subject | PEG 400 | en_US |
dc.subject | soft capsule | en_US |
dc.subject | tramadol hydrochloride | en_US |
dc.title | Acetaminophen and tramadol hydrochloride-loaded soft capsule: preparation, dissolution and pharmacokinetics in beagle dogs | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 26 | - |
dc.identifier.doi | 10.1080/10837450.2021.1903036 | - |
dc.relation.page | 576-581 | - |
dc.relation.journal | PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY | - |
dc.contributor.googleauthor | Cho, Jung Hyun | - |
dc.contributor.googleauthor | Choi, Han-Gon | - |
dc.relation.code | 2021008855 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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