Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장광석 | - |
dc.date.accessioned | 2021-11-30T02:15:14Z | - |
dc.date.available | 2021-11-30T02:15:14Z | - |
dc.date.issued | 2021-06 | - |
dc.identifier.citation | JOURNAL OF MATERIALS CHEMISTRY B, v. 9, no. 24, page. 4956-4962 | en_US |
dc.identifier.issn | 2050-750X | - |
dc.identifier.issn | 2050-7518 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/166570 | - |
dc.description.abstract | Several studies have reported that a drug nanocarrier conjugated with ligands having cell binding ability improves drug delivery performance, but multiple cell-targeting and the resultant activation in designated cells has not been investigated yet. This study reports a skin cell multi-targeting vesicular nanocargo system. We selectively conjugated several skin protein-derived cell-targeting peptides (CTPs), including KTTKS, NAP-amide, and Lam332, to amphiphilic polymer-reinforced lipid nanovesicles (PLNVs) to specifically target fibroblasts, melanocytes, and keratinocytes, respectively, through effective association with the corresponding cell membrane receptors. We then showed that CTP-conjugated PLNVs specifically bind to the designated skin cells, even in a mixture of different types of skin cells, eventually leading to skin cell multi-targeting and consequent activation. These results highlight that this CTP-conjugated PLNV system has significant potential for developing an intelligent cellular drug delivery technology for dermatological applications. | en_US |
dc.description.sponsorship | This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HP20C0018) and also by Bio-industrial Strategic Technology Development Program funded by the Ministry of Trade, Industry and Energy, Republic of Korea (grant number: 20000462). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ROYAL SOC CHEMISTRY | en_US |
dc.title | Skin protein-derived peptide-conjugated vesicular nanocargos for selected skin cell targeting and consequent activation | en_US |
dc.type | Article | en_US |
dc.relation.no | 24 | - |
dc.relation.volume | 9 | - |
dc.identifier.doi | 10.1039/d1tb00935d | - |
dc.relation.page | 4956-4962 | - |
dc.relation.journal | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.contributor.googleauthor | Cho, Jung Hyeon | - |
dc.contributor.googleauthor | Kang, Jeong Yi | - |
dc.contributor.googleauthor | Kim, Seulgi | - |
dc.contributor.googleauthor | Baek, Hwi Ra | - |
dc.contributor.googleauthor | Kim, Junoh | - |
dc.contributor.googleauthor | Jang, Kwang-Suk | - |
dc.contributor.googleauthor | Kim, Jin Woong | - |
dc.relation.code | 2021001865 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E] | - |
dc.sector.department | DEPARTMENT OF CHEMICAL AND MOLECULAR ENGINEERING | - |
dc.identifier.pid | kjang | - |
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