Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조철호 | - |
dc.date.accessioned | 2021-11-22T02:14:09Z | - |
dc.date.available | 2021-11-22T02:14:09Z | - |
dc.date.issued | 2020-05 | - |
dc.identifier.citation | Electrolyte & Blood Pressure, v. 18, no. 1, page. 1-9 | en_US |
dc.identifier.issn | 1738-5997 | - |
dc.identifier.issn | 2092-9935 | - |
dc.identifier.uri | https://e-bp.org/DOIx.php?id=10.5049/EBP.2020.18.1.1 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/166389 | - |
dc.description.abstract | Background: Urinary concentration impairment is a major feature of cyclosporine nephrotoxicity. Methods: We explored two possible mechanisms that may underlie cyclosporineinduced polyuria; water, and/or osmotic diuresis. Cyclosporine was subcutaneously injected to normal salt-fed Sprague-Dawley rats at a daily dose of 25mg/kg for 2 weeks (Experiment I) and 7.5mg/kg for 6 weeks (Experiment II). Results: In Experiment I, cyclosporine treatment caused an increase in urine volume (2.7±0.5 vs. 10.3±1.13mL/d/100 g BW, p<0.001) and a decrease in urine osmolality (2,831±554 vs. 1,379±478mOsm/kg H2O, p<0.05). Aquaporin-2 (AQP2) protein expression decreased in cyclosporine-treated rat kidneys (cortex, 78±8%, p<0.05; medulla, 80±1%, p<0.05). Experiment II also showed that urine volume was increased by cyclosporine treatment (4.97±0.66 vs. 9.65±1.76mL/d/100 g BW, p<0.05). Whereas urine osmolality was not affected, urinary excretion of osmoles was increased (7.5±0.4 vs. 14.9±1.4mosmoles/d/100 g BW, p<0.005). Notably, urinary excretion of glucose increased in cyclosporine-treated rats (7±1 vs. 10,932±2,462 mg/d/100 g BW, p<0.005) without a significant elevation in plasma glucose. In both Experiment I and II, GLUT2 protein expression in the renal cortex was decreased by cyclosporine treatment (Experiment I, 55±6%, p<0.005; Experiment II, 88±3%, p<0.05). Conclusion: Both water diuresis and osmotic diuresis are induced by cyclosporine nephrotoxicity. AQP2 and GLUT2 downregulation may underlie water and osmotic diuresis, respectively. | en_US |
dc.description.sponsorship | This study was supported by grants from Myoung Poom Medical (201700000000881) and Yuhan Pharmaceutical (201700000001988) Co. | en_US |
dc.language.iso | en | en_US |
dc.publisher | The Korean Society of Electrolyte and Blood Pressure(대한전해질대사연구회) | en_US |
dc.subject | Aquaporin-2 | en_US |
dc.subject | Cyclosporine | en_US |
dc.subject | GLUT2 | en_US |
dc.subject | Osmotic diuresis | en_US |
dc.subject | Water diuresis | en_US |
dc.title | Urinary Concentration Defect and Renal Glycosuria in Cyclosporine-treated Rats | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 18 | - |
dc.identifier.doi | 10.5049/EBP.2020.18.1.1 | - |
dc.relation.page | 1-9 | - |
dc.relation.journal | Electrolyte & Blood Pressure | - |
dc.contributor.googleauthor | Lee, Jun Han | - |
dc.contributor.googleauthor | Kim, Su A | - |
dc.contributor.googleauthor | Jo, Chor Ho | - |
dc.contributor.googleauthor | Lee, Chang Hwa | - |
dc.contributor.googleauthor | Kim, Gheun-Ho | - |
dc.relation.code | 2012212236 | - |
dc.sector.campus | S | - |
dc.sector.daehak | RESEARCH INSTITUTE[S] | - |
dc.sector.department | INSTITUTE FOR THE INTERGRATION OF MEDICINE AND INNOVATIVE TECHNOLOGY | - |
dc.identifier.pid | chjo1101 | - |
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