Evaluation of electrochemical methods for tonic dopamine detection in vivo
- Title
- Evaluation of electrochemical methods for tonic dopamine detection in vivo
- Author
- 장동표
- Keywords
- Dopamine; Electrochemistry; Voltammetry; Tonic dopamine; Sensors; Neurochemistry
- Issue Date
- 2020-05
- Publisher
- ELSEVIER SCI LTD
- Citation
- TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 132, article no. 116049
- Abstract
- Dysfunction in dopaminergic neuronal systems underlie a number of neurologic and psychiatric disor-ders such as Parkinson's disease, drug addiction, and schizophrenia. Dopamine systems communicate via two mechanisms, a fast "phasic" release (sub-second to second) that is related to salient stimuli and a slower "tonic" release (minutes to hours) that regulates receptor tone. Alterations in tonic levels are thought to be more critically important in enabling normal motor, cognitive, and motivational functions, and dysregulation in tonic dopamine levels are associated with neuropsychiatric disorders. Therefore, development of neurochemical recording techniques that enable rapid, selective, and quantitative measurements of changes in tonic extracellular levels are essential in determining the role of dopamine in both normal and disease states. Here, we review state-of-the-art advanced analytical techniques for in vivo detection of tonic levels, with special focus on electrochemical techniques for detection in humans.
- URI
- https://www.sciencedirect.com/science/article/pii/S0165993620302788?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/166387
- ISSN
- 0165-9936; 1879-3142
- DOI
- 10.1016/j.trac.2020.116049
- Appears in Collections:
- GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > ETC
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